The Functions of Ocu-miR-205 in Regulating Hair Follicle Development in Rex Rabbits
March 2020
ocu-miR-205 hair follicle development dermal papilla cells DPCs PI3K/Akt signaling pathway Wnt signaling pathway Notch signaling pathway BMP signaling pathway cell proliferation apoptosis cell cycle protein phosphorylation secondary follicle density total follicle density growth phase regression phase resting phase hair density
TLDR ocu-miR-205 affects hair density in Rex rabbits by altering hair follicle growth and signaling pathways.
The study investigated the role of ocu-miR-205 in hair follicle development in Rex rabbits, revealing that it was more highly expressed in low hair density dermal papilla cells (DPCs) compared to high density ones. ocu-miR-205 was found to increase cell proliferation and apoptosis, alter cell cycle processes, and affect the expression of genes in the PI3K/Akt, Wnt, Notch, and BMP signaling pathways. It inhibited certain protein phosphorylation levels while promoting others, leading to changes in secondary and total follicle densities without affecting primary follicle density. Overall, ocu-miR-205 promoted the transition of hair follicles from the growth phase to regression and resting phases, impacting hair density in Rex rabbits.
