The Functions of Ocu-miR-205 in Regulating Hair Follicle Development in Rex Rabbits
April 2020
ocu-miR-205 dermal papilla cells DPCs PI3K/Akt signaling pathway Wnt signaling pathway Notch signaling pathway BMP signaling pathway protein phosphorylation hair follicle development miRNA apoptosis cell proliferation cell cycle processes microRNA-205 phosphoinositide 3-kinase/Akt pathway bone morphogenetic protein signaling pathway
TLDR Ocu-miR-205 affects hair density in Rex rabbits by influencing cell processes and signaling pathways.
The study investigated the role of ocu-miR-205 in hair follicle development in Rex rabbits, focusing on its impact on dermal papilla cells (DPCs). It was found that ocu-miR-205-5p was more highly expressed in low hair density DPCs compared to high density ones. This miRNA increased cell proliferation and apoptosis, altered cell cycle processes, and influenced the expression of genes in the PI3K/Akt, Wnt, Notch, and BMP signaling pathways. It also affected protein phosphorylation levels, promoting the transition of hair follicles from the growth phase to regression and resting phases. While primary follicle density remained unchanged, secondary and total follicle densities were affected, with an increased secondary/primary ratio observed 14 days post-injection. Overall, ocu-miR-205 played a significant role in regulating hair density by promoting DPC apoptosis and altering signaling pathways.
