November 2021 in “CRC Press eBooks” This review discusses the genetic and metabolic factors influencing hair pigmentation, as well as conditions leading to hypo- or depigmented hair, and reports no new experimental findings.
2 citations
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May 2023 in “Photobiomodulation, photomedicine, and laser surgery” This editorial reviews how photobiomodulation therapy might effectively treat both hyperpigmentation and depigmentation skin disorders, but reports no new clinical results.
1 citations
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November 2017 in “International Journal of Research in Medical Sciences” In this study, hair follicle effacement was identified as a key dermoscopic feature of cicatricial alopecia, and dermoscopy proved useful in distinguishing cicatricial from non-cicatricial alopecias.
This study found that specific and nonspecific skin changes can serve as important indicators for diagnosing thyroid diseases, even in patients who appear clinically normal.
30 citations
,
May 2014 in “American Journal of Clinical Dermatology” This review discusses follicular and scarring disorders in skin of color and highlights the need for patient education and tailored therapeutic strategies, but does not report new clinical findings.
7 citations
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May 2014 in “Clinical practice” This article reviews drug-induced hair and nail disorders and discusses their clinical recognition, underlying mechanisms, and potential treatment strategies, without presenting new research findings.
June 2024 in “Stem cell research & therapy” This systematic review examined 64 randomized controlled clinical trials on regenerative medicine for specific dermatologic disorders, reporting up to 68.4% improvement in androgenetic alopecia and up to 71% improvement in vitiligo among 2888 patients.
18 citations
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October 2022 in “Biomedicines” This review presents clinical and preclinical evidence supporting innovative regenerative approaches to treat vitiligo, as existing treatments lack a specific cure and predictable long-term repigmentation outcomes.
12 citations
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May 2023 in “EMBO reports” In this study with organ-cultured human scalp hair follicles, high mTORC1 activity correlated with gray/white hair and reduced pigmentation, while inhibiting mTORC1 with rapamycin increased hair growth and pigmentation, suggesting mTORC1 inhibition could be a strategy for treating hair depigmentation and loss.
5 citations
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January 2012 in “Journal of Tissue Science & Engineering” In this study, collagen I decellularized scaffolds enhanced the growth and melanotic properties of hair follicle melanocytes, suggesting their potential as effective carriers for transplantation in vitiligo treatment.
April 2019 in “Institutional Repositories DataBase (IRDB)” This study demonstrated that human iPSC-derived melanocytes, when transplanted into mice, can reconstitute pigmented hair follicles and integrate into normal tissue, suggesting their potential as a cellular therapy for depigmentation.
August 2024 in “Bioscience of Microbiota Food and Health” In this review, researchers examined the link between microorganisms and vitiligo, highlighting how microbes might impact the disease's development and suggesting avenues for better treatment strategies based on these interactions.
37 citations
,
October 2017 in “Advanced drug delivery reviews” This review explores the mechanisms of skin repigmentation and therapeutic strategies for pigmentation disorders following burn injuries, but it presents no new clinical results.
3 citations
,
June 2025 in “Stem Cell Research & Therapy” Hair follicle-derived melanocyte transplant could effectively treat vitiligo by restoring skin color.
2 citations
,
May 2025 in “IntechOpen eBooks” This article highlights that early and high-dose corticosteroid therapy, along with immunosuppressive agents, is crucial for managing Vogt-Koyanagi-Harada disease, and emerging biological therapies may benefit refractory cases.
January 2026 in “Contemporary Clinical Dentistry” This case report describes a rare instance of Vogt-Koyanagi-Harada disease in a 21-year-old Asian woman, highlighting unusual oral manifestations such as tooth discoloration and misalignment, which expand the known clinical spectrum of the disorder.
105 citations
,
February 2017 in “British Journal of Dermatology” This review discusses the range of long-term complications, including mucocutaneous, ocular, and psychological sequelae, for survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis, but reports no new clinical results.
27 citations
,
January 2011 in “Dermatology Research and Practice” This review discusses the autoimmune pathogenesis of non-segmental vitiligo and highlights the genetic susceptibility linking it to other autoimmune disorders, but reports no new clinical results.
16 citations
,
January 2006 in “The Aging Male” This review discusses various skin diseases with endocrinological origins and reports no clinical results, highlighting the need for interdisciplinary understanding in diagnosis.
1 citations
,
February 2023 in “Pediatric Dermatology” This case report of an infant with IPEX syndrome highlights the importance of early recognition and treatment, as the patient experienced severe symptoms and succumbed before stem cell transplantation.
16 citations
,
December 2006 in “Expert Review of Dermatology” This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.
This study describes vitiligo as a chronic disorder where genetic, environmental, and immune factors contribute to skin depigmentation, with associations to other autoimmune diseases and potential links to oxidative stress.
November 2021 in “Natural product research” This study observed that the aqueous extract of roasted Alocasia macrorrhizos tubers led to hair follicle repigmentation and reduced epidermal thickness in a murine model of Vitiligo.
August 2025 in “Annals of Medicine” This study found that mycophenolate mofetil can enhance skin pigmentation in vitiligo models by activating the WNT signaling pathway and increasing melanin-related gene expression.
March 2026 in “Preprints.org” In this study, plerixafor was found to enhance melanogenesis and promote repigmentation by engaging a β-arrestin–β-catenin–MITF signaling axis in melanocytes, and showed effectiveness in restoring depigmentation in a murine model without causing systemic toxicity.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review explores the causes and management of premature greying in children, noting it may indicate underlying health issues, and emphasizes structured evaluations and treatments, particularly for nutritional deficiencies and hypothyroidism, to address hair depigmentation.
January 2016 in “Lithuanian University of Health Sciences” This study in a Lithuanian veterinary clinic observed diverse histomorphological skin changes in alopecic dogs caused by various rare diseases, including hyperkeratinization and pigmentation disorders.
240 citations
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April 2011 in “Pigment Cell & Melanoma Research” This review discusses the identification and characteristics of melanocyte stem cells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.
9 citations
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January 2018 in “Medical research archives” This review discusses the therapeutic use of photobiomodulation for various skin conditions, highlighting its efficacy in accelerating tissue repair, reducing inflammation, and treating pigmentary disorders and other skin diseases, but it reports no new clinical results.
7 citations
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January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that thymus transplantation in athymic mice resulted in T-cell-driven hair follicle depigmentation and loss, without multiorgan autoimmune disease, highlighting mechanisms of tissue-specific tolerance.