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      Androgenetic Alopecia

      research Androgenetic alopecia.

      18 citations , February 2014 in “PubMed”
      This article reviews current diagnostic and treatment approaches for androgenetic alopecia but reports no new results, focusing on its progression and medical management options.

      research Endocrine Functions of the Testes

      3 citations , November 2021 in “IntechOpen eBooks”
      This chapter reviews the role of the testes in producing and functioning of testicular androgens and protein hormones, but it presents no new clinical results.
      5 Alpha-Reductase and Metabolic Syndrome in PCOS Patients

      research 5 Alpha - Reductase and Metabolic Syndrome in PCOS Patients

      February 2021 in “International Journal of Science and Research (IJSR)”
      This study found that the total testosterone/dihydrotestosterone ratio is significantly higher in women with polycystic ovary syndrome and is associated with a worse metabolic profile in both PCOS and healthy women.
      The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

      research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

      1040 citations , October 1992 in “The New England Journal of Medicine”
      In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.
      Treatment of Hair Loss

      research Treatment of Hair Loss

      370 citations , September 1999 in “The New England Journal of Medicine”
      This article discusses the treatment of androgenetic alopecia and alopecia areata with finasteride and minoxidil but reports no new clinical results.
      Sexual Hormones in Human Skin

      research Sexual Hormones in Human Skin

      305 citations , February 2007 in “Hormone and metabolic research”
      This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.
      5α-Reductase Activity in the Prostate

      research 5α-reductase activity in the prostate

      237 citations , December 2001 in “Urology”
      This review discusses the role of 5α-reductase in prostate development and BPH, and reports no new clinical results; ongoing trials are exploring dual isozyme inhibitors for improved treatment efficacy.
      Molecular Mechanisms of Androgenetic Alopecia

      research Molecular mechanisms of androgenetic alopecia

      229 citations , August 2002 in “Experimental Gerontology”
      This paper discusses key mechanisms of androgen metabolism in androgenetic alopecia and reports the effectiveness of treatments like oral finasteride and topical minoxidil, highlighting the limited success rate due to factors like follicular inflammation.
      Biology of the Hair Follicle: The Basics

      research Biology of the Hair Follicle: The Basics

      224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”
      This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.

      research An overview on 5α-reductase inhibitors

      219 citations , October 2009 in “Steroids”
      5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.
      Androgens and Hair Growth

      research Androgens and hair growth

      209 citations , September 2008 in “Dermatologic Therapy”
      This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.

      research Discovery of Nonsteroidal Androgens

      209 citations , March 1998 in “Biochemical and biophysical research communications”
      This study identified a novel class of nonsteroidal ligands that can mimic the effects of dihydrotestosterone on androgen receptors, suggesting potential therapeutic applications in male fertility and hormone replacement therapy.

      research On the effects of testosterone on brain behavioral functions

      186 citations , February 2015 in “Frontiers in Neuroscience”
      This review discusses the complex effects of testosterone on the brain, emphasizing sex differences, and reports no clinical results; the authors highlight the inconsistencies in current study findings.
      Androgens and Alopecia

      research Androgens and alopecia

      165 citations , December 2002 in “Molecular and Cellular Endocrinology”
      This study found that finasteride improves scalp hair growth in men with male pattern hair loss by reducing scalp dihydrotestosterone levels, but it did not benefit postmenopausal women with female pattern hair loss.

      research Gonadal Function Abnormalities in Sickle Cell Anemia

      163 citations , November 1976 in “Annals of Internal Medicine”
      This study found that adults with sickle cell anemia exhibited androgen deficiency due to primary testicular failure, and there was a significant correlation between erythrocyte zinc levels and serum testosterone.

      research Androgen biosynthetic pathways in the human prostate

      160 citations , April 2008 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”
      This review outlines the complexities of understanding DHT biosynthesis and metabolism in the human prostate and reports no new findings, emphasizing the need for further research into the pathways involved.

      research Testosterone, cytochrome P450, and cardiac hypertrophy

      155 citations , October 2002 in “The FASEB Journal”
      This study found that altered testosterone metabolism and changes in cytochrome P450 mono-oxygenase expression are significantly associated with cardiac hypertrophy in human hearts and spontaneously hypertensive rats.