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This study found that dysregulation of systemic Th1, Th2, and Th17 cytokines is associated with alopecia areata, with specific cytokines linked to disease activity and treatment response.

This review discusses the clinical trials of clascoterone 1% cream for acne vulgaris and reports no new results; the authors highlight its novel role as a topical antiandrogen.

This study found that spatial transcriptomics can reveal hidden inflammation patterns in atopic dermatitis by correlating epidermal and dermal gene expression levels, improving understanding of skin pathology.

This study found that specific gene upregulations and mutations in hidradenitis suppurativa skin support the role of inflammation, altered epithelial differentiation, and metabolism dysregulation in the disease's pathogenesis.

This study reported that dupilumab, an FDA-approved biologic, is a safe and effective first-line systemic treatment for children with moderate-to-severe atopic dermatitis, showing sustained skin improvement and itch reduction, with injection site reactions and conjunctivitis as potential side effects.

This study found that a 3D co-culture of adipose-derived stem cells and endothelial colony forming cells restored stem cell properties and enhanced wound healing in a mouse model.

SACUMAN, a rare condition causing hair loss without clear signs, is often misdiagnosed and needs scalp biopsies for accurate detection.

This review suggests that PDRN shows promise as a safe and versatile regenerative agent for wound healing and other dermatological applications, based on its dual mechanisms and clinical evidence of efficacy.

This study found that plucked hair follicles can serve as a practical and scalable source for regenerative medicine, as researchers successfully isolated and expanded keratinocytes and mesenchymal stem cells for potential cell-based and cell-free therapies, demonstrating significant wound-healing bioactivity in vitro.

This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.

This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.

This review discusses immune pathways involved in alopecia areata and explores emerging, more targeted therapeutic strategies, noting their potential for better safety and effectiveness compared to traditional immune suppressants.

In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.

This review reports on the potential for deucravacitinib, an oral TYK2 inhibitor approved for psoriasis, to treat various immune-mediated diseases, with emerging research suggesting possible uses in neurodegenerative diseases and certain cancers.

This study found that prostate cancer aggressiveness in men with obesity is associated with changes in age, BMI, testosterone, and estradiol levels, and that adipocyte-secreted molecules increase cancer cell aggressiveness in vitro.

This review discusses current genomics and proteomics research on cutaneous autoimmune diseases, noting overlapping gene patterns but highlighting the scarcity of data on local gene expression in affected tissues.

This article discusses the immune mechanisms involved in alopecia areata, focusing on T-cell activity and cytokine-driven JAK signaling, but reports no new clinical results.

This study found that compounds from *Tectona grandis* leaves showed moderate inhibition of steroid 5α-reductase, a factor in androgenetic alopecia, and exhibited anti-inflammatory properties by inhibiting nitric oxide and pro-inflammatory cytokines IL-1β and IL-6 in vitro, suggesting potential dual-action benefits for AGA management.

This study found that dupilumab treatment in alopecia areata significantly suppressed Th2-related markers and increased hair keratin levels, suggesting a potential role of Th2 cytokines in the disease's pathogenesis.

This source reports that clascoterone cream has been approved in the U.S. for treating acne vulgaris in patients aged 12 and older, suggesting it works by competing with dihydrotestosterone at androgen receptors to mitigate acne's effects.

This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.

This review discusses the use of Janus kinase inhibitors for severe alopecia areata in Japan, noting their effectiveness in some patients but highlighting the need for new therapies due to non-responsiveness and relapse in others; it reports no new clinical results.

This study observed that Poria cocos polysaccharides and finasteride both reduced inflammation in chronic nonbacterial prostatitis in rats, but only Poria cocos polysaccharides reversed related changes in the gut microbiota.

This study found that soluble CD83 (sCD83) accelerated chronic and hard-to-heal wound healing and improved inflammatory and pro-resolving cytokine profiles, suggesting potential for therapeutic use.

This study analyzed gene expression profiles from multiple tissues to explore the molecular connections between obesity and immune-related processes, identifying potential links and pathways that may require further experimental validation to understand their roles in obesity fully.

In this study, researchers used gas chromatography–mass spectrometry to analyze agarwood from Laos and Thailand, identifying key volatile compounds also found in five other regions, and highlighted cytokine-regulated anti-inflammatory activity as a significant biological mechanism, suggesting potential for pharmaceutical and cosmetic applications.

In this study, a very low-calorie ketogenic diet significantly improved metabolic and hormonal profiles in obese men, but did not significantly enhance most semen parameters except for sperm motility.

This study characterized the inflammatory response in a promising murine model of thermal burns, similar to human burns, to inform future burn complication studies and preclinical testing of therapies.

This review examines the role of innate lymphoid cells in allergic diseases and the influence of an allergic microenvironment on their plasticity, without reporting new clinical outcomes.

This case report documented a 25-year-old female patient presenting with systemic lupus erythematosus coinciding with a COVID-19 infection, suggesting a possible link between the two conditions.