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Scientists successfully purified a protein called Wnt3a, which is involved in processes like hair growth, but the overall yield was low, suggesting more work is needed to improve this.

Nitric oxide is important for skin functions and both helps protect against and contributes to skin inflammation and sensitization.

Water and fatty acids affect hair's surface differently based on hair damage, and models can help understand hair-cosmetic interactions.

Human hair keratins can be turned into useful 3D biomedical scaffolds through a freeze-thaw process.

Lamins are vital for cell survival, organ development, and preventing premature aging.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

Keratin-associated proteins have ancient origins and were used for different purposes before being adapted for hair in mammals.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

K6hf is a unique protein found only in a specific layer of hair follicles.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.

The HR protein's role as a repressor is essential for controlling hair growth.

Frequent hair coloring and styling can damage hair and cause breakage or loss.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Mutations in the KRT85 gene cause hair and nail problems.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

pH, calcium, and reactive oxygen species regulate plant cell growth, with key roles for NADPH oxidases and plasma membrane H+-ATPases.

Pannexin 3 is important for bone formation and the development of bone cells.

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.