research Morphogenesis and Maintenance of the 3D Thymic Medulla and Prevention of Nude Skin Phenotype Require FoxN1 in Pre- and Post-Natal K14 Epithelium
FoxN1 gene is essential for proper thymus structure and preventing hair loss.
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research Disease Versus Disease: How One Disease May Ameliorate Another
Some diseases can improve the outcomes of other diseases, leading to new treatment possibilities.
research Metabolic, Behavioral, and Reproductive Effects of Vertical Sleeve Gastrectomy in an Obese Rat Model of Polycystic Ovary Syndrome
Vertical sleeve gastrectomy improved metabolism, behavior, and reproduction in obese rats with PCOS.
research Choroidal Melanoma and Lid Fibrofolliculomas in Birt-Hogg-Dubé Syndrome
A patient with Birt-Hogg-Dubé Syndrome also had choroidal melanoma, suggesting the need for careful eyelid exams in such patients.
research Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms
Stem cells compete for space using cell adhesion, and mutations can affect their competitive success, with implications for tissue health and disease.
research The Possible Implication of the S250C Variant of the Autoimmune Regulator Protein in a Patient with Autoimmunity and Immunodeficiency: In Silico Analysis Suggests a Molecular Pathogenic Mechanism for the Variant
The S250C variant in a gene may cause autoimmunity and immunodeficiency by impairing protein function.
research Keratin 71 Mutations: From Water Dogs to Woolly Hair
A mutation in the KRT71 gene causes a hair disorder by disrupting hair follicle structure and texture.
research Arginosuccinic Aciduria in a 4-Year-Old Girl: Neurological Symptoms and Hair Abnormalities
A 4-year-old girl with arginosuccinic-aciduria showed symptoms including mental retardation, seizures, ataxia, and abnormal hair, with normal ammonia and blood urea nitrogen levels despite an enzymic block in the urea cycle. Hair strength was significantly reduced, and although trichorrexis nodosa was not diagnosed, the hair's cystine content was notably low. The neurological symptoms' cause in this amino acid disorder remained speculative.
research Ovarian Hilus-Cell Hyperplasia and High Serum Testosterone in a Patient With Postmenopausal Virilization
A woman's male-like symptoms and high testosterone were due to ovarian hilus-cell hyperplasia, which improved after surgery.
research A Case of Encephalocraniocutaneous Lipomatosis
The document reports a rare case of ECCL with a new association with optic disc colobomas.
research Poikiloderma Congenital: An Early Case of Rothmund-Thomson Syndrome
A patient with Rothmund-Thomson syndrome showed skin changes, hair loss, and dental defects but no cataracts or skeletal issues.
research Effect of a Combination of Ethinylestradiol and Desogestrel in Adolescents with Oligomenorrhea and Ovarian Hyperandrogenism
The study involved 9 oligomenorrheic adolescent girls with ovarian hyperandrogenism and 8 eumenorrheic controls, treated with a monophasic oral contraceptive containing 0.03 mg ethinylestradiol and 0.150 mg desogestrel for 6 months. The treatment reduced levels of LH, FSH, androstenedione, testosterone, and DHEA-S, while increasing SHBG in both groups. In oligomenorrheic girls, it also decreased ovarian volume and cystic follicles. However, most hormonal levels returned to pre-treatment values 3 months after stopping the treatment, except for SHBG and ovarian volume. Six oligomenorrheic girls reported improved skin and reduced hair growth. Despite its temporary effects, the treatment was effective in managing hyperandrogenism and may help prevent adult micropolycystic ovarian disease.
research Rare Clinical Features of the Ellis Van Creveld Syndrome: A Case Report and Literature Review
Ellis van Creveld syndrome, a rare genetic disorder, can cause unexpected abnormalities in various body organs, requiring thorough patient evaluations.
research The Punctiform Technique in Hair Transplantation
Carlos Oscar Uebel developed a hair transplant method that looks natural, has low risk, and shows full growth in 6-12 months.
research A Previously Undescribed Cutaneous Paraneoplastic Syndrome in a Cat with Thymoma
Thymoma in cats can cause hair loss without inflammation.
research Effects of Chemical Straighteners on the Hair Shaft and Scalp
Chemical hair straighteners can cause scalp and hair damage, but long-term effects are unclear.
research De Novo Assembly and Annotation of Asiatic Lion (Panthera Leo Persica) Genome
The Asiatic lion has very low genetic diversity and unique genetic traits, highlighting the need for its conservation.
research Felinine Excretion in Domestic Cat Breeds: A Preliminary Investigation
Shorthaired and hairless cat breeds excrete more felinine than longhaired breeds.
research Advanced Hyperandrogenism in a Postmenopausal Woman: Case Report
A postmenopausal woman's high testosterone levels and symptoms improved after removing a tumor from her ovary.
research Topical Treatment of Androgenetic Alopecia with Spironolactone
Topical spironolactone effectively treats hair loss in women.
research Mycobacteriosis in a Pet Ferret (Mustela putorius furo) Caused by Mycobacterium Xenopi: A Case Report on Neglected Risk of Zoonotic Transmission
A pet ferret had a serious infection from Mycobacterium xenopi, which can spread to humans.
research Agaricus Subrufescens Ameliorates Ovarian Dysfunction and Regulates Altered Biochemical Parameters in Rats with Letrozole-Induced Polycystic Ovarian Syndrome
Agaricus subrufescens improves ovarian function and biochemical health in rats with PCOS.
research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia
Removing a specific gene in certain skin cells causes hair loss in mice by disrupting hair follicle development.
research Trends in the Global Organoid Technology and Industry: From Organogenesis in a Dish to the Commercialization of Organoids
Organoid technology is advancing and entering commercial use, with applications in disease modeling, drug development, and personalized medicine.
research Enzymatic Approach to Analyze the Effects of Mercaptans on Hair
The study analyzed the effects of different mercaptans on hair by examining protease degradation in reduced and permed hair samples. It found that reduced hair exhibited significantly higher protease degradation compared to permed hair, and the degradability of permed hair increased with repeated treatments. The degradability of reduced hair was closely linked to its cystine content, whereas permed hair's degradability was largely unaffected by cystine content. The study concluded that the degradability of both hair types was influenced by the reduction power of the mercaptans used, with the order of increasing degradability being CYS-treated hair, CA-treated hair, and TG-treated hair.
research Adrenocortical Adenoma as a Cause of Hyperandrogenism Syndrome in a Girl: The Path to Diagnosis
A young girl's hyperandrogenism was caused by an adrenocortical adenoma, diagnosed and treated through detailed evaluations.
research Case Report: Exploring Autosomal Recessive Woolly Hair: Genetic and Scanning Electron Microscopic Perspectives on a Japanese Patient
A genetic mutation in the LIPH gene causes tightly curled hair that stops growing in some Japanese individuals.
research Characterization of Type II Rickets Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor
The research showed that Vitamin D and its receptor are important for healthy bones and normal hair and skin in rats.
research Molecular Insight of Active Plant-Based Drug Molecules for the Treatment of Polycystic Ovary Syndrome
Plant-based substances like chamomile and aloe vera may help treat PCOS symptoms.
research Agaricus Subrufescens Ameliorates Ovarian Dysfunction in Rats with Letrozole Induced Polycystic Ovarian Syndrome
Agaricus subrufescens extract improved ovarian function and normalized various health markers in rats with PCOS.