research Identification and Characterization of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2
A new mutation in the AGPAT2 gene causes severe fat tissue loss and related health issues by reducing the protein's levels.
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research Differential Expression of mTOR Signaling Pathway Proteins in Lichen Planopilaris and Frontal Fibrosing Alopecia
The mTOR pathway proteins are altered in the hair follicles of patients with Lichen Planopilaris and Frontal Fibrosing Alopecia.
research Case Report of Schöpf–Schulz–Passarge Syndrome Resulting from a Missense Mutation, p.Arg104Cys, in WNT10A
A new gene mutation caused a man's rare skin condition, Schöpf-Schulz-Passarge syndrome.
research Ovarian Hemangioma: A Rare Entity
Ovarian hemangioma is a rare, benign tumor that can be treated effectively with surgical removal.
research Detection of Five Substitution TPO Mutations in Polycystic Ovary Syndrome and Thyroid Hormones Disturbance Patients
Five different TPO gene mutations were found in PCOS patients with thyroid hormone issues.
research Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups During the First Hair Cycle
Erythropoietin overexpression disrupts hair growth and fat formation in mice.
research 28-Year-Old Woman with Hyperprolactinemia and Its Relationship to Polycystic Ovary Syndrome
Treating hyperprolactinemia can help manage PCOS symptoms.
research Cancer Risk in Polycystic Ovary Syndrome Patients: Common Treatments and Future Perspectives
PCOS may increase the risk of certain cancers.
research Irregular Menstruation, Acne, Hirsutism, and the Possibility of PCOS
Women with irregular periods should be checked for PCOS and treated early to prevent complications, with birth control pills helping to manage symptoms.
research What’s New in Birt–Hogg–Dubé Syndrome?
New findings suggest the protein linked to Birt–Hogg–Dubé syndrome is important in cell signaling and could affect treatment understanding.
research FoxN1 in K14 Promoter-Driven Epithelium Is Required for Generation and Maintenance of 3D-Thymus Medulla and Preventing Nude Phenotype in the Skin
FoxN1 gene is crucial for proper thymus structure and normal skin appearance.
research Reviews of Medical Books
The books were useful but had some areas needing improvement.
research Expert Medical Testimony on Penicillamine Side Effects
Penicillamine can cause taste problems due to copper loss, which can be fixed with copper or zinc supplements.
research Plastic Surgical Considerations in Pediatric Dermatologic Abnormalities
Treat pediatric skin issues with accurate diagnosis, multidisciplinary team, and various treatment options.
research The Disintegrin/Metalloproteinase Adam10 Is Essential for Epidermal Integrity and Notch-Mediated Signaling
Adam10 enzyme is crucial for healthy skin and proper Notch signaling.
research Medical Treatment of Liver Hydatidosis
Surgery is the main treatment for liver hydatidosis, but has risks; albendazole is the most effective drug but can have side effects.
research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase
In this study, researchers created a transgenic mouse line that overexpressed spermidine/spermine N^1-acetyltransferase, leading to significant alterations in tissue polyamine pools. These changes included the presence of N^1-acetylspermidine, an unusual accumulation of putrescine, and reduced levels of spermidine and spermine. The most notable phenotypic effect was permanent hair loss in mice aged 3 to 4 weeks, associated with the formation of follicular cysts in the dermis, likely due to putrescine's interference with hair follicle cell differentiation and proliferation. Additionally, female mice were infertile, linked to ovarian hypofunction and underdeveloped uteri. This research highlighted the potential of using spermidine/spermine N^1-acetyltransferase overexpression to manipulate polyamine levels in transgenic animals for studying developmental and cancer-related outcomes.
research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
Wnt signaling is crucial for skin development and hair growth.
research New Agents for Cancer Chemoprevention
Over 30 potential cancer prevention treatments are being tested, with some showing promise in early research.
research Sulfotransferases, Sulfatases, and Formylglycine-Generating Enzymes: A Sulfation Fascination
The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.
research Non-Contraceptive Benefits of Oral Hormonal Contraceptives
Oral contraceptives provide various health benefits beyond birth control, including managing menstrual issues, skin conditions, pain, and reducing the risk of certain cancers.
research Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity
The study investigated the role of ornithine decarboxylase (ODC) in hair follicle function using transgenic mice that overexpressed a mutated ODC transgene in hair follicle keratinocytes. These mice experienced normal initial hair growth but lost their hair completely 2-3 weeks after birth, coinciding with the onset of ODC overexpression and the development of follicular cysts. The study found that the ODC inhibitor 2-difluoromethylornithine could prevent hair loss and partially restore normal skin histology if administered early, and it could also reactivate hair growth in mice with complete hair loss. The results suggested that ODC played a crucial regulatory role in mouse hair follicles.
research Misoprostol Therapeutics Revisited
Misoprostol, a prostaglandin E1 analog, was found to have diverse therapeutic applications beyond its known gastrointestinal protective and uterotonic activities. It played a role in regulating immunologic responses, protecting against various injuries and diseases, and improving nutrient absorption in conditions like cystic fibrosis. Misoprostol showed potential in treating hepatotoxicity, asthma, cardiovascular and renal conditions, periodontal disease, and ocular issues such as glaucoma. It also enhanced the effects of certain anti-inflammatory drugs and was used in pain management. Notably, it reduced chemotherapy-induced hair loss and aided recovery from burn injuries, demonstrating its wide-ranging medical benefits.
research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration
Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.
research The Place of Intralesional Steroid Therapy in Dermatology
Intralesional steroid therapy is useful for treating various skin conditions.
research Bovine Besnoitiosis in Germany
A cow in Germany was diagnosed with bovine besnoitiosis, showing skin issues and confirmed by tests.
research Stem Cells Supporting Other Stem Cells
Stem cells can help other stem cells by producing supportive factors.
research Modern Dermabrasion Techniques: A Personal Appraisal
Improved dermabrasion techniques in 1987 led to better treatment results for skin issues like acne scars.
research Hair and Nail Diseases in the Elderly Population
Older adults commonly experience hair loss and nail disorders due to aging and health changes, affecting their quality of life.
research Arthroderma Vanbreuseghemii Infection in Three Family Members with Kerion and Tinea Corporis
A family got a fungal infection from a boy who had contact with rabbits, but they all recovered with treatment.