New Agents for Cancer Chemoprevention

    January 1996 in “ Journal of cellular biochemistry ”
    Gary J. Kelloff, Charles W. Boone, James A. Crowell, Vernon E. Steele, Ronald A. Lubet, Linda A. Doody, Winfred F. Malone, Ernest T. Hawk, Caroline C. Sigman
    TLDR Over 30 potential cancer prevention treatments are being tested, with some showing promise in early research.
    The document discussed the progress in clinical chemoprevention trials for cancer, highlighting over 30 agents and combinations being tested. Advanced agents in large Phase III trials included retinoids, calcium, β-carotene, vitamin E, tamoxifen, and finasteride. Newer agents in Phase II and early Phase III trials included 4-HPR, DFMO, NSAIDs, oltipraz, and DHEA. A third group of agents, showing promise in animal models and early studies, were undergoing preclinical toxicology testing or Phase I trials. These included S-allyl-l-cysteine, curcumin, genistein, ibuprofen, and others. Future studies would focus on more efficacious and safer analogs of known drugs, as well as novel combinations and inhibitors targeting specific pathways.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Anyone excited for CosmeRNA coming this month?

      in Product  171 upvotes 1 year ago
      CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

      community Hair loss - Blood work (High DHEAS)

      in Research/Science  8 upvotes 3 years ago
      A user has been taking finasteride for 5 months with no improvement in diffuse hair loss and suspects high levels of prolactin, cortisol, progesterone, and DHEAS, as well as iron, might be contributing to the issue. They are also taking vitamin D to address a deficiency.

      community Blood test 3 days after finasteride. Is it ok?

      in Finasteride/Dutasteride  3 upvotes 6 months ago
      A user asked if taking a blood test 3 days after starting finasteride would affect the results for Estradiol, FSH, SHBG, Progesterone, and DHEA-S. The conversation is about the timing of blood tests after beginning finasteride treatment.

      community I think I’m on to something

       24 upvotes 5 years ago
      The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

      community My Experience and a Discourse on "DUPA"

      in Treatment  9 upvotes 6 months ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

    Similar Research

    6 / 1000+ results