New Agents for Cancer Chemoprevention

The document discussed the progress in clinical chemoprevention trials for cancer, highlighting over 30 agents and combinations being tested. Advanced agents in large Phase III trials included retinoids, calcium, β-carotene, vitamin E, tamoxifen, and finasteride. Newer agents in Phase II and early Phase III trials included 4-HPR, DFMO, NSAIDs, oltipraz, and DHEA. A third group of agents, showing promise in animal models and early studies, were undergoing preclinical toxicology testing or Phase I trials. These included S-allyl-l-cysteine, curcumin, genistein, ibuprofen, and others. Future studies would focus on more efficacious and safer analogs of known drugs, as well as novel combinations and inhibitors targeting specific pathways.