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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Inhaling medicine may reduce side effects and improve treatment for a major lung cancer type.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

Microorganism overgrowth and hyperkeratosis may trigger immune reactions causing lichen planopilaris.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.

Editing the FGF5 gene in sheep increases fine wool growth.

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Key genes can rewire networks, changing skin appendage types.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Platelet-rich plasma may help hair follicle cells grow by affecting certain genes and pathways.

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The document explains how male reproductive hormones work and affect the body.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

Porphyra-334 may help reduce wrinkles and promote hair growth.

Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.

Finasteride in male rats causes liver and metabolic issues in their offspring.

PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.

Trilostane may help delay epilepsy development by increasing certain brain chemicals.

More research is needed to understand how testosterone is maintained in adult males.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Adrenal disorders can cause lasting brain and behavior issues in children.

Certain drugs that block specific enzymes can help treat prostate diseases.