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This review reports that cubosomes, used as drug nanocarriers in topical treatments, offer potential benefits for managing skin and eye diseases by improving bioadhesion, retention, and sustained release compared to conventional formulations, but also face manufacturing and biological challenges for effective clinical outcomes.

This study found that cubosomal suspensions significantly enhanced the hair growth-promoting effects of Thuja orientalis, Polygonum multiflorum Thunberg, and Espinosilla extracts in a mouse model, making them as effective as Minoxidil.

This article describes a method using the CUBIC protocol to clarify and visualize molecular and cellular interactions in mouse skin biopsies at single cell resolution, but does not provide new biological findings.

This study found that cubosomes combined with dissolving microneedles enhanced transdermal penetration and hair growth efficacy of beta-sitosterol for treating alopecia.

In this study, cetirizine hydrochloride was formulated into niosomal and cubosomal gels, showing potential for off-label use in treating androgenic alopecia due to effective skin permeation and acceptable safety profiles; cubosomal gels exhibited superior permeation compared to niosomal gels.

This case report describes four patients with hypertrichosis cubiti and short stature, but could not determine a genetic link between hypertrichosis cubiti and skeletal dysplasia.

This case report describes a unilateral contact dermatitis caused by shoe dye containing 4-aminoazobenzene, which was confirmed with patch testing, highlighting its atypical presentation.

This case report describes a six-year-old girl with hypertrichosis cubiti, characterized by excess terminal hair growth around the elbows, and notes treatment with over-the-counter depilatory creams and shaving to address aesthetic concerns.

In this study, the researchers developed minoxidil cubosomes using nanotechnology, which improved drug penetration in the skin, showed greater hair growth efficacy, and reduced adverse skin reactions compared to traditional minoxidil solutions.

A new mouse mutation causes skin and hair issues, influenced by another gene.

This study found that encapsulating tamarillo polyphenols in cubosome nanoparticles protected them during digestion and enhanced the nutritional and antioxidant properties of yoghurt when used as a delivery system.

This study reported successful outcomes in over 40 patients undergoing reparative surgical techniques for previously unsuccessful hair restoration, with significant improvements in appearance despite potential challenges like limited donor hair and scalp scarring.

This study found that SCUBE3 protein is upregulated in various cancers, promoting tumor growth and poor outcomes, while suppressing growth in renal cell carcinoma, and may serve as a diagnostic marker and potential therapeutic target for several diseases due to its secreted nature.

This study suggests that adopting the Mark Cuban Cost Plus Drug Company model for purchasing urological medications could have saved Medicare about $1.29 billion in 2020.

In this case report, interferon-alpha treatment for a man with hemophilia and hepatitis C was associated with unexpected diffuse hair growth, likely caused by the medication.

This study suggests that deficiencies in certain amino acids, like taurine and tryptophan, in artificial milk formulas may contribute to skin and eye problems in Bengal tiger cubs.

This study found that the antimicrobial peptide DPK-060 effectively reduced bacterial counts of Staphylococcus aureus and was safe for topical use in preclinical models, although nanocarrier encapsulation did not enhance its efficacy.

This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

This study found that using monoolein cubic phase nanoparticles with an entrapped hydroxypropyl β-cyclodextrin/minoxidil complex increased minoxidil skin permeation, but minoxidil retention in the skin was higher with a traditional solution.

This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.

This study found that D-004, a hexanic extract from the Cuban royal palm fruit, did not cause genotoxic effects in male germ cells of mice over an 8-week period.

In this study, cubosome and hexosome carriers with antimicrobial peptides showed varied efficacy, with cubosomes protecting peptides from degradation and enhancing bactericidal effects in some cases, while hexosomes lacked antimicrobial activity.

This study investigated the interdigital glands in sheep, highlighting their apocrine sweat glands' ultrastructural characteristics and positive lectin reaction, but reported no new clinical results.

This study discovered previously unknown structures in human hair shafts that may stabilize hair structurally and physicochemically.

In this study, researchers identified that certain inflammatory cytokines, including osteoprotegerin and leukemia inhibitory factor, are inversely associated with hypertrophic scar risk, whereas others like CDCP1, GDNF, and PD-L1 show a positive association, suggesting potential pathways for intervention in scar formation.

In this study, Indonesian spices were screened in silico for their potential to inhibit MMP9 and TNFα, which are involved in chronic diabetic wounds, and procyanidin was identified as the most promising therapeutic candidate due to its low binding energy to both proteins.

This study identified Aquilaria sinensis and Piper cubeba as tropical plants with potential anti-androgenic and anti-estrogenic properties that could help prevent or alleviate benign prostatic hyperplasia and prostate cancer.

In this study, among Chinese infants and young children aged 0-5 years, Type II and Type III frontal hairline patterns were the most common, with a negative correlation observed between age and hairline type.

This study found that the Mark Cuban Cost Plus Drug Company offers significant cost savings on men's health medications compared to both Medicare and GoodRx, particularly for erectile dysfunction treatments.

This study found that an increased calcium/magnesium ratio in hair and lower chromium concentration were associated with higher insulin resistance in Korean adult males.