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Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

The regenerative solution, tSVF, is a safe and effective treatment for various conditions like aged skin, scars, wounds, and more, but more research is needed to find the best way to use it.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.

Aging men face unique health issues like erectile dysfunction, prostate problems, and baldness.

Caragana korshinskii seed oil effectively treats fungal skin infections.

High androgen levels can cause excessive hair growth and may indicate serious health issues, including heart disease and fertility problems.

Disrupting natural body clocks increases the risk of developing type 2 diabetes.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Lupus is a complex disease that requires personalized treatment because it varies greatly between individuals.

Dermatologists give better information on pathology forms, hypersensitivity vasculitis is a common skin issue, misdiagnoses can occur, and various skin conditions are linked to loss of elastin or genetic factors.

Natural products like propolis are causing more skin allergies, and certain skin treatments and medications have various side effects and risks.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Shift work disrupts the body's natural clock, leading to health problems.

Natural volatiles and essential oils have health benefits and can enhance the effects of some medicines, but more research is needed to understand how they work and their possible side effects.

Gut health affects skin diseases, and probiotics might help.

The transcription factor Meis2 is essential for touch sensation and proper nerve development in touch receptors.

Innovative methods are reducing animal testing and improving biomedical research.

Early recognition and aggressive treatment can significantly improve rare ANA-negative lupus with heart and skin issues.

Meis2 is essential for touch sensation and nerve function in mice.

The S250C variant in a gene may cause autoimmunity and immunodeficiency by impairing protein function.

AGA risk factors include age, smoking, hypertension for men, and age, dyslipidemia for women; lifestyle changes may help prevention.

High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.