118 citations
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October 2014 in “Journal of Dairy Science” This study found that in lactating Holstein cows, hair from the tail switch, which grows faster and is more sensitive to cortisol changes, is ideal for measuring hair cortisol levels.
16 citations
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January 2021 in “Frontiers in veterinary science” This study found no significant difference in hair cortisol concentrations, a chronic stress indicator, between sows in farrowing crates and those in loose-housing systems.
22 citations
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May 2019 in “Animals” In this study, researchers found that high hair cortisol levels, indicating stress in cows, were associated with certain shelter and cow-level conditions such as unclean environments and physical injuries.
21 citations
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January 2017 in “MethodsX” This study found that methanol is more effective than isopropanol at removing external cortisol from grizzly bear hair and suggests that the choice of solvent can influence hair cortisol concentration results.
11 citations
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April 2020 in “Animals” This study reported that relocation in police horses was associated with elevated hair cortisol concentrations, possibly suggesting altered welfare due to changed surroundings, and that seasonal variations affected both cortisol levels and hair growth.
6 citations
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September 2014 in “Food Additives & Contaminants: Part A” This study developed a new method for detecting 30 hormones in anti-aging functional foods, demonstrating good sensitivity and reliability, and identified seven hormones in four out of 14 samples tested.
4 citations
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June 2025 in “JMIR Formative Research” In this study, researchers reported no statistically significant association between hair cortisol levels and either perceived stress or objective neuroendocrine stress measures in a predominantly male participant group.
3 citations
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November 2021 in “Stress” This study found that school-related stress increases hair cortisol in girls and alters hair testosterone and cortisol levels in boys, indicating gender-specific hormonal responses to environmental changes.
January 2026 in “Western Journal of Nursing Research” This study found that collecting hair samples for cortisol analysis is feasible in community-dwelling individuals with longstanding multiple sclerosis, although no significant correlation between hair cortisol levels and perceived chronic stress was observed, highlighting the complexity of stress measurement in this population.
May 2026 in “Preprints.org” This study examined sheltered and adopted domestic cats, finding that dark coat color and living environment significantly influence hair cortisol and DHEA levels as stress indicators, while age and sex do not; adoption was associated with reduced long-term stress, underscoring its benefits for feline welfare.
134 citations
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March 2015 in “Clinical Endocrinology” This study introduced a validated LC-MS/MS-based method for profiling long-term steroid concentrations in human scalp hair, offering potential applications in endocrinology research.
1 citations
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November 2022 in “Nutrients” This study found that piglets' rapid growth during nursery and lactation was linked to changes in microbiota composition and increased cortisol conversion, highlighting critical early life factors influencing adult microbiota establishment.
March 2024 in “American journal of veterinary research” This study found that clippers are the safest and most efficient tool for collecting hair samples from companion dogs, with no impact on cortisol concentration compared to scissors.
119 citations
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August 2010 in “Journal of Investigative Dermatology” This study reports that 11β-HSD1 activity in human skin increases with age and photoexposure, potentially contributing to skin aging and the effects of glucocorticoids.
78 citations
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November 2014 in “Functional Ecology” This study found that wolves in heavily hunted areas of Canada's tundra–taiga exhibited higher levels of stress and reproductive hormones, indicating social instability and increased reproductive effort due to human-caused mortality.
54 citations
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May 2015 in “Endocrinology” In this study, manipulation of the enzyme 5α-reductase type 2 in human hepatocytes altered lipogenesis, suggesting clinical implications for patients using 5α-reductase inhibitors by affecting glucocorticoid action on hepatic lipid metabolism.
44 citations
,
November 2018 in “Journal of applied ecology” This review discusses the use of hair analysis for examining stress and reproduction hormone levels in wildlife and highlights the need for more comprehensive physiological validations across species.
11 citations
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January 2020 in “World Journal of Traditional Chinese Medicine” This study used a glucocorticoid-injection model to mimic kidney-yang deficiency syndrome and reported symptoms related to hormonal imbalances in the hypothalamic-pituitary-target gland axes.
5 citations
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April 2022 in “Journal of Chromatography B” The new method can measure sleep-related hormones in hair effectively and could help track long-term sleep patterns.
December 2025 in “Neurobiology of Stress” This study found that individuals with a recent history of suicide attempts exhibited altered DHEA hair levels, suggesting possible dysregulation of the HPA axis as a biopsychosocial feature, and recommends further investigation into hair hormones as potential markers of suicidal crisis and vulnerability.
November 2025 in “European Journal of Endocrinology” This study found that hair steroid profiling is a feasible, non-invasive alternative to serum analysis in adolescents, with androgen levels correlating more strongly with body size and composition in boys than girls.
September 2025 in “International Journal of Molecular Sciences” In this review, researchers explored hair as a promising tool for identifying biomarkers in schizophrenia, highlighting its potential for supporting personalized medicine through ease of sampling, though acknowledging challenges like individual variability and methodological inconsistencies.
In this study, researchers used the CRISPR/Cas9 system to edit the FGF5 gene in Dorper sheep, observing increased density and finer wool, along with changes in cortisol levels and antioxidant enzyme activity linked to hair follicle development.
66 citations
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May 2014 in “Conservation Physiology” This study found that lower salmon availability was associated with higher stress hormone levels in grizzly and black bears, influencing their physiological responses and competitive behaviors.
September 2025 in “Cosmoderma” This study highlights how the COVID-19 pandemic has exacerbated stress-related dermatological issues like acne and hair loss by affecting skin and hair cycles through stress hormones, emphasizing the need for comprehensive psychoneuroendocrine-informed approaches to diagnosis and treatment.
This review highlights that recent advancements in diagnostics and therapies, including AI-enhanced imaging, biomarker analysis, and novel treatments like low-dose oral minoxidil and JAK inhibitors, are improving the precision and customization of hair loss management.
September 2024 in “Journal Of Social Sciences And Humanites” In this study, combining medical treatments, natural remedies, dietary guidance, and stress management achieved the best outcomes for hair regrowth and patient satisfaction in Cambodia, highlighting the importance of a multifaceted approach for effective hair loss prevention and treatment.
June 2023 in “International journal of molecular sciences” In this study, researchers observed that heat stress significantly affected hair and skin traits in two indigenous goat breeds, with Kodi Aadu goats demonstrating greater thermal resilience compared to Kanni Aadu goats, potentially due to differences in gene expression and methylation.
15 citations
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October 2017 in “Dermatologic Clinics” This abstract discusses advancements in hair transplantation technology, highlighting the role of robotics and follicular unit extraction/grafting in achieving excellent clinical outcomes, with adjuvant treatments like platelet-rich plasma, lasers, and stem cells potentially improving the durability and appearance of results.
81 citations
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July 2008 in “The Journal of Clinical Endocrinology and Metabolism” This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.