The Effect of Hormones of the Hypothalamic-Pituitary-Target Gland Axes in a Kidney-Yang Deficiency Syndrome Model

    January 2020 in “ World Journal of Traditional Chinese Medicine ”
    Ling Zhao, AgraDarmawati Ayu, Wen Pan, Zouqin Huang
    TLDR Kidney-yang deficiency syndrome causes hormonal imbalances and various physical symptoms.
    The study investigated the effects of glucocorticoid drugs on the hypothalamic-pituitary-target gland axes in a kidney-yang deficiency syndrome (KYDS) model. It successfully mimicked KYDS symptoms, such as exhaustion and cold limbs, and showed decreased hormone levels in the HPT and HPG axes. Histological analysis revealed atrophy in several tissues, including the hypothalamus and pituitary. The study emphasized the role of the HPA axis in stress response and the impact of glucocorticoid-induced redox imbalance on hormone regulation. Traditional Chinese medicine, like You Gui Pill and Sini Decoction, showed potential in alleviating KYDS symptoms by modulating hormone pathways and reducing oxidative stress. The findings provided insights into the hormonal network's complexity and its role in KYDS, offering a basis for future research.
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