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      Effect of Indole-Based Derivatives on Rats with Polycystic Ovary Syndrome

      research Indole-based derivatives effect on rats with polycystic ovary syndrome

      April 2017 in “Journal of Pharmaceutical Investigation”
      In this study, the administration of indole-based compounds, particularly L-Tryptophan and Tryptophol, to a PCOS-induced rat model resulted in an increased number of healthy ovarian follicles and a reduction in ovarian cysts compared to untreated rats, suggesting potential therapeutic efficacy.

      research [PRACTICAL EXPERIENCES WITH OVULATION INHIBITION].

      January 1965 in “PubMed”
      This study found that Anovlar effectively reduced pain in severe dysmenorrhea cases and regulated cycles in oligomenorrhea patients, but some side effects and occasional treatment failures were reported.
      Physiological Changes in the Skin During Pregnancy

      research Physiological changes in the skin during pregnancy

      96 citations , January 1997 in “Clinics in Dermatology”
      This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
      Skin Connective Tissue and Aging

      research Skin connective tissue and ageing

      77 citations , July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”
      This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.
      The Therapeutic Use of Androgens in Women

      research The therapeutic use of androgens in women

      51 citations , April 1999 in “The Journal of Steroid Biochemistry and Molecular Biology”
      This review examines androgen replacement therapy in women for treating androgen deficiency symptoms and reports no new clinical results, while noting potential safety within a specific dose range.
      Period Problems: Disorders of Menstruation in Adolescents

      research Period problems: disorders of menstruation in adolescents

      34 citations , June 2010 in “Archives of Disease in Childhood”
      This review discusses normal menstrual variations and common menstrual disorders in adolescent girls, focusing on symptoms, evaluation, and management, but does not present new clinical results.
      The Rationale for Physiological Testosterone Replacement in Women

      research The rationale for physiological testosterone replacement in women

      28 citations , October 1998 in “Baillière's clinical endocrinology and metabolism”
      This review examines age-related changes in androgen levels in women and explores the rationale for testosterone replacement therapy, but it reports no new clinical findings.
      Oligomenorrhea in Exercising Women

      research Oligomenorrhoea in Exercising Women

      11 citations , November 2009 in “Sports Medicine”
      This review explores whether oligomenorrhoea in exercising women is a mild subclinical phenotype of PCOS or part of a spectrum of energy deficiency-related menstrual disturbances, without new clinical results.
      Hyperandrogenism from an Ovarian Interstitial-Cell Tumor in an Alpaca

      research Hyperandrogenism from an Ovarian Interstitial-Cell Tumor in an Alpaca

      11 citations , November 2006 in “Journal of Veterinary Diagnostic Investigation”
      In this case study, an 8-year-old female Huacaya alpaca displaying male behavior was diagnosed with an ovarian benign interstitial (Leydig) cell tumor, indicated by elevated testosterone levels.
      Androgens and the Menopause

      research Androgens and the Menopause

      6 citations , September 1998 in “The Journal of The British Menopause Society”
      This review discusses the changes in androgen levels with age in women and the potential benefits of testosterone replacement therapy as part of hormone replacement therapy for postmenopausal women, but it reports no new clinical results.
      The Use of Testosterone After Menopause

      research The use of testosterone after menopause

      5 citations , June 2004 in “The Journal of The British Menopause Society”
      This study found that testosterone therapy can enhance sexual satisfaction and mood in surgically menopausal women on oestrogen, though ongoing monitoring and research are needed to assess long-term safety and effects in other groups.
      Menopause

      research Menopause

      3 citations , January 2007 in “Elsevier eBooks”
      The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.
      Steroid Hormones in Geriatrics

      research STEROID HORMONES IN GERIATRICS

      1 citations , February 1954 in “Journal of the American Geriatrics Society”
      Steroid hormones can help treat aging issues and improve health in elderly people.
      Evaluation of Serum Ferritin, Creatinine, and Liver Enzymes in Patients with Beta-Thalassemia After Administration of Deferasirox

      research Evaluation of Serum Ferritin, Creatinine and Liver Enzymes in Patients with ß- thalassemia After Administration of Deferasirox

      April 2023 in “Tikrit Journal of Pharmaceutical Sciences”
      In this study, researchers assessed the effects of deferasirox in 85 children with ß-thalassemia in Kirkuk and reported that while 55.3% experienced a reduction in serum ferritin, 9.4% had adverse effects, indicating that deferasirox is generally well-tolerated as an iron chelator with modifiable side effects.
      Infertility in Polycystic Ovarian Disease/Syndrome

      research Infertility in PCOD

      September 2022 in “Journal of Contemporary medical practice”
      This study found that among women with polycystic ovarian disease, 72% experienced infertility, indicating a correlation between PCOD and difficulties in conceiving.
      Infertility in Polycystic Ovarian Disease

      research Infertility in PCOD

      April 2022 in “International Journal of Science and Research (IJSR)”
      This study found a correlation between polycystic ovarian disease and infertility among women, with 72% of participants experiencing difficulty conceiving.
      5 Alpha-Reductase and Metabolic Syndrome in PCOS Patients

      research 5 Alpha - Reductase and Metabolic Syndrome in PCOS Patients

      February 2021 in “International Journal of Science and Research (IJSR)”
      This study found that the total testosterone/dihydrotestosterone ratio is significantly higher in women with polycystic ovary syndrome and is associated with a worse metabolic profile in both PCOS and healthy women.
      Androgen Biosynthesis and Gene Defects

      research Androgen Biosynthesis and Gene Defects

      November 2014 in “Elsevier eBooks”
      This article reviews the clinical and biochemical features of genetic mutations affecting dihydrotestosterone production and their potential role in male pseudo-hermaphroditism, but presents no new clinical results.
      Skin and Hair Changes After Forty

      research SKIN AND HAIR CHANGES AFTER FORTY

      April 2014 in “Journal of evolution of medical and dental sciences”
      This article reviews the skin and hair changes associated with menopause due to hormonal shifts and reports no new clinical results.
      Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

      research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

      451 citations , March 2005 in “Endocrine Reviews”
      This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.