Effect of Indole-Based Derivatives on Rats with Polycystic Ovary Syndrome

    April 2017 in “ Journal of Pharmaceutical Investigation ”
    Parichehreh Yaghmaei, Babak Dehestani, Samira Ghorbani, Farzaneh Abbasi, Azadeh Ebrahim-Habibi
    Image of study
    TLDR Indole-based compounds improved ovarian health in rats with PCOS, with L-Tryptophan and Tryptophol being most effective.
    In the 2017 study, 42 adult female rats with induced polycystic ovary syndrome (PCOS) were treated with indole-based compounds for 8 weeks. The compounds included 5-hydroxy indole-2-carboxylic acid, N-acetyl-tryptophan, Tryptamine, L-Tryptophan, and Tryptophol. Results showed an increase in primary follicles, corpus luteum, growing follicles, and graafian follicles, and a decrease in the number and diameter of ovarian cysts in all treated rats compared to the untreated group. L-Tryptophan and Tryptophol were the most effective, suggesting their efficacy may be due to interactions with melatonin receptors, antioxidant properties, and pharmacokinetics.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    5 / 5 results

      community Theory And Observation: Why Being Bald Can Really Work

      in Shaved/buzzed  88 upvotes 9 months ago
      The original poster believes shaving his head made him more attractive to a specific group of women, despite being less attractive overall. The conversation includes various opinions on attractiveness, with some agreeing that being bald can work for certain men, while others suggest maintaining hair is generally more appealing.

      community Nandrolone Replacement Therapy

      in Treatment  41 upvotes 1 year ago
      A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

    Similar Research

    5 / 283 results