May 2020 in “Research Square (Research Square)” This study found that trichilemmal carcinoma shares genetic changes with other skin cancers, suggesting a similar pathogenesis, particularly in those with aggressive clinical courses linked to TP53 mutations.
April 2020 in “Research Square (Research Square)” This study reported genetic mutations in trichilemmal carcinoma similar to those found in other skin cancers, including TP53 mutations associated with aggressive disease.
15 citations
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July 2012 in “Biological trace element research” This study found that an increased calcium/magnesium ratio in hair and lower chromium concentration were associated with higher insulin resistance in Korean adult males.
20 citations
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January 2015 in “Current problems in dermatology” This paper reviews recent research on hair graying, suggesting that an imbalance in oxidative stress handling may affect melanocyte stem cells and melanin production with age, and calls for exploring strategies to prolong melanin production.
11 citations
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January 2012 in “Journal of cell science” This study demonstrates that Rac1 activity is essential for normal hair follicle formation but influences hair structure and pigmentation, in terminal differentiation, through alterations in hair shaft, cuticle, and pigmentation organization.
1 citations
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July 2025 in “Journal of Human Immunity” This study found that administering minoxidil and PGE2 to pregnant mice with 22q11.2 deletion syndrome models corrected multiple developmental anomalies, including thymus growth and parathyroid positioning, by targeting prenatal mesenchymal differentiation.
November 2024 in “Aging Cell” In this study, researchers found that treating senescent human dermal papilla cells with dasatinib and quercetin improved their ability to regenerate hair follicles by depleting senescent cells and enhancing inductive potency, suggesting potential clinical applications for senolytic treatments in cell-based hair restoration therapies.
January 2026 in “Journal of Trace Elements in Medicine and Biology” This study found that living environment significantly influenced Fe concentrations in dog and cat hair, with outdoor animals showing higher levels than those kept indoors.
4 citations
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January 2020 in “Skin appendage disorders” This study highlighted that toxic metals, particularly thallium, arsenic, selenium, and mercury, are commonly associated with cases of alopecia areata.
1 citations
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December 2023 in “Nanomaterials” In this study, the researchers synthesized copper-doped mesoporous silica nanoparticles and observed that they enhance tumor microenvironment regulation and, when paired with disulfiram, effectively kill cancer cells while also showing synergistic anti-tumor effects with immune checkpoint inhibitors.
October 2004 in “Kafrelsheikh Veterinary Medical Journal” In this study, buffalo calves fed only corn silage showed deficiencies in copper, zinc, selenium, and vitamin A, along with improved physiological conditions after dietary supplementation and treatment.
7 citations
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January 2018 in “PubMed” In this study, reduced serum levels of iron, copper, and calcium were associated with premature graying of hair, suggesting that supplementation might help, but more research is needed to fully understand the relationship.
July 2026 in “Frontiers in Veterinary Science” This study found that combined dietary supplementation of sodium hyaluronate and eggshell membrane was associated with various improvements in skin and coat health markers in healthy Ragdoll cats.
June 2025 in “Clinical Cosmetic and Investigational Dermatology” This study examined the factors contributing to gray hair, such as genetics and lifestyle, and found that while graying correlates with some health conditions, it is primarily a physiological process rather than a pathological one.
July 2024 in “Medical alphabet” In this review, researchers discuss the factors contributing to early graying, such as genetic predisposition, oxidative stress imbalance, and nutrient deficiencies, and highlight potential restoration methods involving palmitoyl tetrapeptide-20 and the endocannabinoid system in hair follicles.
July 2022 in “Dermatologica Sinica” In this study, zinc deficiency, iron depletion, and thyroid abnormalities were commonly observed in female pattern hair loss patients, suggesting the benefit of testing for these conditions.
146 citations
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September 2013 in “Advances in nutrition” This review examines nutritional deficiencies after bariatric surgery, particularly in essential minerals like zinc and copper, and highlights the need for more research to improve post-surgery nutritional outcomes.
19 citations
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June 2020 in “BMC Cancer” This study reported that genetic changes in trichilemmal carcinoma resemble those in other skin cancers, with TP53 mutations associated with aggressive clinical outcomes.
2 citations
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November 2023 in “Bioactive materials” The researchers reported that a newly developed ionic liquid-based microemulsion significantly improved the local delivery of copper peptides in mice, enhancing hair growth-related factor activation while offering a safer, non-invasive alternative to existing treatments for hair loss.
1 citations
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April 2021 in “IntechOpen eBooks” This review examines genetic variation in the ovine KRTAP1.1 gene and its potential impact on wool quality, reporting no new findings but suggesting opportunities for developing gene markers for wool and pelt traits.
January 2024 in “Collagen and leather” This study observed that using an environmentally friendly bovine milk permeate effectively and cleanly removes wool from sheepskins without harming the skin, and results in smoother leather compared to traditional chemical methods.
26 citations
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January 2018 in “Annals of dermatology/Annals of Dermatology” This review examines current understanding of hair graying and suggests it may be caused by depletion of melanocyte stem cells due to genotoxic stress or dysfunctional melanocytes from oxidative stress.
11 citations
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January 2016 in “BMC veterinary research” This study found that urinary selenium to creatinine ratio and serum selenium concentrations quickly respond to changes in dietary selenium, making them useful biomarkers for assessing selenium status in dogs.
2 citations
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January 2006 in “Indian Journal of Veterinary Pathology” In this study of sheep across various breeds and ages, researchers found that Trichophyton mentagrophytes caused severe dermatophytosis, especially affecting young Shahbadi sheep during winter, leading to notable anemia and skin lesions.
3 citations
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August 2024 In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.
99 citations
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July 2012 in “PLoS Genetics” This study identified a 69 bp deletion in the KRT75 gene as the cause of the frizzle feather trait in chickens, affecting feather curling.
17 citations
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January 2024 in “Journal of Materials Chemistry B” In this study, researchers developed a hyaluronic acid-coated copper peroxide nano-antimicrobial system that demonstrated precise antimicrobial activity and accelerated wound healing by releasing reactive oxygen species in response to bacterial enzymes, in both laboratory and animal tests.
13 citations
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July 2012 in “Pigment Cell & Melanoma Research” In this study, researchers identified a new dominant mutation in Hairless mice, called Pied, resulting from a deletion in the Adam10 gene, which causes freckle-like skin pigmentation by inhibiting melanocyte expansion.
1 citations
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November 2019 in “Damanhour Journal of Veterinary Sciences” This study found that cows with alopecia, ill-thrift, and infertility exhibited significant decreases in serum copper, zinc, calcium, inorganic phosphorus, magnesium, and hematological measures, indicating moderate microcytic, hypochromic anemia.
13 citations
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July 2019 in “PLoS ONE” This study found that deleting podoplanin in mouse keratinocytes promoted hair follicle growth during regeneration, suggesting it may regulate hair cycling pathways that could aid in treating hair loss conditions.