Minoxidil Restores Thymic Growth in 22q11.2 Deletion Syndrome by Limiting Sox9+ Chondrocyte Expansion

    July 2025 in “ Journal of Human Immunity ”
    Pratibha Bhalla, Neha Ahuja, Ashwani Kumar … Nicolai S. C. van Oers
    Studysummary This study found that administering minoxidil and PGE<sub>2</sub> to pregnant mice with 22q11.2 deletion syndrome models corrected multiple developmental anomalies, including thymus growth and parathyroid positioning, by targeting prenatal mesenchymal differentiation.
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    Research cited in this study 11

    1. Cardiac Outflow Tract Septation Defects in a DiGeorge Syndrome Model Respond to Minoxidil Treatment bioRxiv (Cold Spring Harbor Laboratory) · 2024
    2. Mesenchymal Cell Replacement Corrects Thymic Hypoplasia in Murine Models of 22q11.2 Deletion Syndrome Journal of Clinical Investigation · 2022
    3. Transcriptional Regulation of the Thymus Master Regulator Foxn1 Science immunology · 2022
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    8. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997
    9. Minoxidil Specifically Decreases the Expression of Lysine Hydroxylase in Cultured Human Skin Fibroblasts Biochemical Journal · 1992
    10. Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil Journal of Biological Chemistry · 1987
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