research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives
New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
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research Acute and 30-Day Oral Toxicity Studies of a Novel Coccidiostat – Ethanamizuril
Ethanamizuril is safe for rats at 20 mg/kg feed, but higher doses cause hair loss, organ changes, and liver, kidney, and lung damage.
research Effective Treatment of Refractory Alopecia Areata in Pediatric Patients With Oral Abrocitinib
A new drug, abrocitinib, helped a child with severe hair loss regrow hair.
research Rare Concurrence of Alopecia Areata in the Setting of the Lipedematous Scalp
A patient with a thick scalp and hair loss was correctly diagnosed with alopecia areata and a thick scalp fat layer, not lipedematous alopecia, and regrew hair after treatment.
research Clues to the Cause of Male Pattern Baldness
Targeting a specific lipid could help treat male pattern baldness.
research New Food Supplement Cures Alopecia
A new food supplement was highly effective in curing hair loss in young men.
research Mutations in the Desmoglein 4 Gene Are Associated with Monilethrix-Like Congenital Hypotrichosis
Mutations in the DSG4 gene can cause a rare hair disorder similar to monilethrix.
![Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions](/images/research/2aedba8c-b0ac-4fa3-9ac7-9f375a016bba/small/15581.jpg)
research Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions
Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.
research On the Use of Micro-Imager to Directly Visualize Drug Distribution in Human Skin
Micro-Imager® helps see how drugs spread in human skin.
research Versican Expression by Dermal Papilla-Regenerated Hair Follicles: A Promising Tool for Hair-Regrowth Products
Versican is important for hair growth and could help find new hair regrowth treatments.
research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.
research Procyanidin B-2 and the Hair-Growing Activity of Proanthocyanidins
Procyanidin B-2 from apple juice significantly increases hair growth and may be more effective than minoxidil without side effects.
research Hair Growth Effect of TS-SCLF from Schisandra Chinensis Extract Fermented with Lactobacillus Plantarum
TS-SCLF from fermented Schisandra chinensis may promote hair growth and improve hair quality.
research Micronization Process of Hinokitiol Using Supercritical Carbon Dioxide
Using supercritical carbon dioxide can change the size of Hinokitiol particles.
research Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway
Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.
research Pharmacological Activity Of Cepharanthine
Cepharanthine has many medicinal uses but needs improvement for better effectiveness.
research Effects of SM-215 on Hair Growth by Hair Follicle Stimulation
SM-215 promotes hair growth by improving the environment around hair follicles.
research Skin Applications of Cannabidiol: Sources, Effects, Delivery Systems, Marketed Formulations and Safety
CBD may improve skin and hair health, but its effective use and safety need more research.
research The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β-Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells
Moracin M, a compound from the Moraceae family, has been shown to significantly enhance hair growth by promoting cell proliferation and angiogenesis in human dermal papilla cells (hDPCs). The study found that Moracin M activates the Wnt/β-catenin signaling pathway, leading to increased levels of growth factors such as VEGF, FGF2, KGF, HGF, and MYC, similar to the effects of minoxidil. It also enhances cell migration in human umbilical vein endothelial cells (HUVECs) without cytotoxicity at concentrations up to 50 µM. Additionally, Moracin M increases protein and mRNA levels of VEGF, FGF2, and KGF under inflammatory conditions and stimulates MMP-2 and MMP-9 expression, contributing to wound healing. These results suggest that Moracin M could be a promising alternative to current hair growth treatments.
research Wedelolactone: A Natural Anti-Inflammatory Coumarin Derivative
Wedelolactone may help treat chronic diseases due to its strong antioxidant properties.
research Chemistry, Pharmacology, and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development
Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.
research Ginsenoside Rb1 Promotes the Growth of Mink Hair Follicle via PI3K/AKT/GSK-3β Signaling Pathway
Ginsenoside Rb1 from Panax ginseng helps mink hair grow by activating certain cell signals.
research Kinetic Analysis of LY320236: Competitive Inhibitor of Type I and Non-Competitive Inhibitor of Type II Human Steroid 5α-Reductase
LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.
research Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion
Fisetin in fruits and vegetables helps hair growth in mice.
research Application of Ethanol Extracts From Alnus Sibirica Fisch. ex Turcz in Hair Growth Promotion
Extracts from Alnus sibirica and oregonin may help with hair growth and prevent hair loss.
research Raspberry Ketone: An Evidence-Based Systematic Review by the Natural Standard Research Collaboration
Raspberry ketone lacks sufficient human research to support health benefit claims and requires more rigorous studies to confirm its safety and effectiveness.
research Effects of Baicalin on Alopecia and the Associated Mechanism
Baicalin may help treat hair loss by promoting hair follicle growth and activating specific cellular pathways.
research Cedrol-Loaded Dissolvable Microneedles Based on Flexible Backing for Promoting Hair Growth
Cedrol-loaded microneedles effectively promote hair growth.
research Interactions Between Damaged Hair Keratin and Juglone as a Possible Restoring Agent: A Vibrational and Scanning Electron Microscopy Study
Juglone from walnut extracts may help repair damaged hair.
research Tribuloside Acts on the PDE/cAMP/PKA Pathway to Enhance Melanogenesis, Melanocyte Dendricity and Melanosome Transport
Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.