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    Glossary Cochlear Hair Cells

    specialized inner ear cells that convert sound into signals

    Cochlear hair cells are specialized sensory cells located in the cochlea of the inner ear. They play a crucial role in hearing by converting sound vibrations into electrical signals that the brain can interpret. There are two types: inner hair cells, which primarily send auditory information to the brain, and outer hair cells, which amplify and fine-tune sound vibrations. Damage to these cells can lead to hearing loss.

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    Research 30 of 247

    1. Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea Research Square (Research Square) · 2022
    2. Reviewer #3 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    3. Reviewer #1 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    4. Reviewer #2 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    5. Decision letter: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    6. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea eLife · 2019 · 15 citations
    7. Author response: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    8. A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids. PubMed · 2024
    9. Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway Molecular Neurobiology · 2022 · 5 citations
    10. Data_Sheet_1_Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice.docx OPAL (Open@LaTrobe) (La Trobe University) · 2021
    11. Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia PLoS ONE · 2007 · 77 citations
    12. Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss Molecular Medicine Reports · 2017 · 2 citations
    13. CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024 · 1 citations
    14. CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    15. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    16. The Hair Cell Analysis Toolbox: A machine learning-based whole cochlea analysis pipeline bioRxiv (Cold Spring Harbor Laboratory) · 2021
    17. Calcium blockers protect against sensory epithelial damage and hearing loss in Cx26-cKO mice Biomedicine & Pharmacotherapy · 2025
    18. Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research Hearing Research · 2011 · 28 citations
    19. The role of cochlea extracellular matrix in age related hearing loss DOAJ (DOAJ: Directory of Open Access Journals) · 2025
    20. Cochlea hair cell rescue after a noise-induced hearing loss using a low level laser therapy (LLLT) 2011
    21. Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice International Journal of Molecular Sciences · 2021 · 8 citations
    22. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    23. Experimental Studies of Inner Ear Hair Cell Regeneration. Equilibrium Research · 1995
    24. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations
    25. Influence of Myosin Regulatory Light Chain and Myosin Light Chain Kinase on the Physiological Function of Inner Ear Hair Cells Journal of the Association for Research in Otolaryngology · 2025
    26. Zinc deficiency triggers hearing loss by reducing ribbon synapses of inner hair cells in CBA/N mice Biochemical and Biophysical Research Communications · 2024
    27. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity Biochimica et biophysica acta. Molecular basis of disease · 2024
    28. Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea Hearing research · 2018 · 15 citations
    29. eLife assessment: CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    30. The structural and functional aspects of hair cell regeneration in the chick as a result of exposure to intense sound Experimental Neurology · 1992 · 63 citations