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GlossaryInner Hair Cells

specialized sensory cells in the cochlea converting sound to signals

Inner Hair Cells (IHCs) are specialized sensory cells located in the cochlea of the inner ear. They play a crucial role in hearing by converting sound vibrations into electrical signals, which are then transmitted to the brain via the auditory nerve. Unlike outer hair cells, which primarily amplify sound, IHCs are directly responsible for sending auditory information to the central nervous system.

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Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

research Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

5 citations, November 2022 in “Molecular Neurobiology”

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

research Development of Gene Therapy for Inner Ear Disease: Using Bilateral Vestibular Hypofunction as a Vehicle for Translational Research

28 citations, January 2011 in “Hearing Research”

Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.

research Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation

2 citations, January 2023 in “Redox Report”

Estradiol may protect ear cells from hearing loss caused by a chemotherapy drug by activating a protective pathway.

Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

research Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

5 citations, July 2021 in “Basic & Clinical Pharmacology & Toxicology”

Melatonin may protect ear cells from damage caused by nicotine.

Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

research Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

8 citations, June 2021 in “International Journal of Molecular Sciences”

Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.

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community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

Zeweny in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Minoxidil is connecting the hair on the inner part of my arms

No-Establishment543 in Satire 1 year ago

This conversation is about a user who has been using Minoxidil for nine months and just noticed hair growing on the inner part of their arms. Responses to this post suggest that they should continue using it, with an increase in frequency from 5% twice a day, as well as trying finasteride if needed.

community How many Dut pills does it take to have Franz Kafka's hairline?

Albertgejmr in Satire 48 upvotes 1 year ago

The post and conversation discuss hair loss treatments and the uncertainty of their results. Some users suggest that artificial hair systems might be the best solution, while others express preference for maintaining a mature hairline rather than aiming for a youthful one.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

keqq in Update 35 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community 9 months on Finasteride 1,25mg + HRT

xKena5999 in Transgender 16 upvotes 9 months ago

The conversation is about the results of using hormone replacement therapy (HRT) with estrogen and finasteride for hair loss, and switching from finasteride to bicalutamide as an anti-androgen treatment. The user shared before and after photos to discuss the effectiveness of these treatments.

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