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180-210 / 1000+ resultsresearch Quantification of the Vitamin D Receptor−Coregulator Interaction
This study found that both the natural ligand 1alpha,25(OH)(2)D(3) and the synthetic agonist LG190178 bind similarly to the vitamin D receptor's coregulator motifs, suggesting similar biological functions.
research [Efficacy of combination chemotherapy with mitoxantrone, vincristine, prednisolone (MVP) for recurrence of breast cancer].
This study found that a mitoxantrone, vincristine, and prednisolone regimen effectively treated recurrent breast cancer with a 70% response rate, though it was associated with significant myelosuppression.
research An engineered ferritin nanocage co-delivery system for targeted hair cells protection and hearing loss attenuation
This study developed a novel ferritin-based delivery system (LR@Fn) that effectively co-delivers RG108 and LLY283 for hearing loss treatment in animal models, reducing hair cell loss and synaptic damage more effectively than dexamethasone.
research Training the Next Generation of Clinician–Innovators: The Virtual Magic Wand Program
This pilot study found that the Virtual Magic Wand program successfully educated dermatologists in problem-driven innovation, enhancing their ability to engage in innovative dermatologic practices.
research Efficacy of QR678 Neo® hair growth factor formulation for the treatment of hair loss in Covid‐19‐induced persistent Telogen Effluvium—A prospective, clinical, single‐blind study
In this study of 20 female patients with Covid-19-induced persistent Telogen Effluvium, intra-dermal QR678 Neo® treatments led to significant reductions in hair fall and increases in hair growth and density, sustained even post-therapy.
research Screening of circRNAs Associated with Secondary Wool Follicle Development in Fine-Wool Sheep and Construction of Their ceRNA Network
This study analyzed circular RNA expression in the developing skin of foetal Gansu Alpine fine-wool sheep, identifying key circRNAs potentially involved in secondary follicle development through regulatory networks, providing insights for wool trait improvement.
research 3D cell culture stimulates the secretion of in vivo like extracellular vesicles
This study found that extracellular vesicles derived from 3D cultures of cervical cancer cells have small RNA profiles more similar to those in patient plasma than those from 2D cultures.
research Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study
This study identified specific profiles and courses of adverse events associated with boron neutron capture therapy for head and neck cancer, suggesting differences based on the beam incidence site.
research Correction of the Cornrow Transplant and Other Common Problems in Surgical Hair Restoration by James E. Vogel, M.D.
This journal summarizes advancements in plastic and reconstructive surgery techniques, including maxillofacial reconstruction and cosmetic procedures, but reports no new research results.
research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality
This study found that Acvr1b signaling is crucial for both hair follicle development and cycling in mice, with the genetic disruption leading to hair loss and a thickened epidermis.
research 2022 Practice Census Shows Impact of COVID-19 Pandemic on Hair Restoration
In this study, researchers found that effective working memory performance in healthy, young adults depends on neural suppression of irrelevant information to prevent overload, rather than just enhancing relevant information.
research 707 Informative leaflet about neovaginal dilatation after MtF reassignment surgery: the importance of correct management of dilatation programme
This article reviews a guideline provided to MtF patients for effective post-surgical vaginal dilatation, emphasizing preoperative education and a structured dilatation routine to aid recovery.
research A comparative study of linear and nonlinear ANNs as classifiers of animal hair fibers
Nonlinear artificial neural networks are better at identifying different types of animal hair than linear ones.
research Regulation of VDR by ΔNp63α is associated with inhibition of cell invasion
This study found that ΔNp63α directly regulates VDR expression, which in turn may reduce invasiveness in an epidermoid cancer cell line.
research Two siblings with a novel nonsense mutation, p.R50X, in the vitamin D receptor gene
In this study, researchers identified a novel p.R50X mutation in the vitamin D receptor gene, linked to hereditary vitamin D-resistant rickets in two siblings.
research Examining the Effect of Notocactus ottonis Cold Vacuum Isolated Plant Cell Extract on Hair Growth in C57BL/6 Mice Using a Combination of Physiological and OMICS Analyses
In this study, N. ottonis cactus cell extract applied to mice promoted hair growth and increased the number of hair follicles, suggesting its potential as a hair-growth-promoting agent.
research A modified FLIT-B model of trigeminal neuralgia reveals anterior cingulate cortex involvement in anxiety-like behavior in mice
In this study, researchers developed an enhanced rodent model of trigeminal neuralgia, demonstrating that structural and functional changes in the anterior cingulate cortex are linked to chronic pain and emotional disturbances, and chemogenetic inhibition of specific neurons could alleviate symptoms.
research Neurospectrum: A Geometric and Topological Deep Learning Framework for Uncovering Spatiotemporal Signatures in Neural Activity
This study introduced Neurospectrum, a framework that effectively identifies meaningful neural dynamics by encoding neural activity into latent trajectories, and reported that it outperformed traditional methods in tracking synchronization, reconstructing stimuli, and identifying fMRI biomarkers in various datasets.
research Diagnostic applications and therapeutic option of Cascade CRISPR/Cas in the modulation of miRNA in diverse cancers: promises and obstacles
This review discusses various applications of CRISPR-based tools in cancer research, emphasizing their potential for investigating microRNA functions and developing microRNA-based therapies, despite challenges like off-target effects and delivery issues in using CRISPR/Cas9.
research A window into the vascular endothelium in COVID-19: Nails
In this study, dermoscopic examination of COVID-19 patients revealed significant microvascular changes in the proximal nailfold, such as avascular areas and disorganized capillary architecture, compared to healthy controls, with some regression of these changes observed over time.
research Comparative Evaluation of Wound Healing Effect of Cord Blood Low Molecular Weight Fraction (Below 5 kDa) and Actovegin Drug in Skin Cryolesions
In this study on rats, CBF injections demonstrated significant wound healing effects and improved recovery after skin cryoablation, similar to the effects observed with Actovegin.
research Objective quantification of chemotherapy-induced madarosis: a pilot study of an automated computer vision pipeline for eyebrow density assessment
This study presents a new automated computer vision system to objectively measure periocular hair density changes in breast cancer patients undergoing chemotherapy, demonstrating high precision in tracking individual changes and potential as a reliable tool for future clinical trials.
research Detection of lentiviral constructs for release testing of CAR- T cells using digital droplet PCR
This study found that digital droplet PCR (ddPCR) outperformed qPCR in detecting replication competent lentivirus in CAR-T products by offering better sensitivity, specificity, and reproducibility, making it a reliable and rapid method for ensuring patient safety.
research Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles
This review explores current strategies to enhance extracellular vesicle-based delivery of CRISPR/Cas systems, addressing efficiency challenges and suggesting future directions to bridge gene editing technologies with clinical applications.
research Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo
This study found that CTHRC1 is crucial for sweat gland function and vascular network integrity in mice, and its administration improved sweat gland performance by reconstructing nearby blood vessels.
research Visualization of individual cell division history in complex tissues
This study developed the iCOUNT tool, which provides insights into stem cell behavior by tracking cell division events and molecular consequences in human and mouse neural stem/progenitor cells.
research Therapeutic Efficacy of Spironolactone for Central Serous Chorioretinopathy
This study found that oral spironolactone improved certain biomarkers in central serous chorioretinopathy patients, but recurrence, especially in older patients, was relatively common.
research Clinically relevant skull models and optical measurement method to evaluate programmable hydrocephalus valve tool kit usability
This study developed simulated skull models and a method to assess programming tool movements, selecting three models as most clinically relevant for hydrocephalus shunt valve programming.
research Bilateral facial nerve palsy associated with p-ANCA positive vasculitis in a patient with rheumatoid arthritis
In this case, intralesional cidofovir showed a successful outcome for treating SCC without systemic toxicity, suggesting it may be worth considering alongside surgical excision.