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This study found that stem cells from semi-solid bone marrow improved healing in diabetic incision wounds by enhancing epidermal thickness and blood vessel growth.

This study found that a microenvironment-responsive ATAN-Met hydrogel system improved infective diabetic wound healing by enhancing re-epithelialization, neurovascular and hair follicle regeneration, and exhibited antibacterial and immunoregulatory effects, activated beneficial pathways, and responded to glucose/ROS for drug release.

In this study, a mouse model with a PIK3CA gain-of-function mutation in Schwann cells revealed unique communication with neighboring cells and a glycolytic shift in peripheral nerves, and early alpelisib treatment significantly improved symptoms, though efficacy declined with delayed administration due to limited drug penetration.

This study found that targeting the molecule Midkine may reduce pain and itching in keloid patients by inhibiting specific Schwann cell activities contributing to these symptoms.

This study engineered a programmable platform using miniaturized needle arrays for drug delivery, showing improved wound healing outcomes in diabetic mice compared to standard topical treatments.

This study found that acid regulation of the TRPV3 channel can inhibit its function from outside the cell while facilitating it from inside, providing insights into skin barrier and disorder mechanisms related to tissue acidosis.

This study developed the CATNIP computational model, which uses biological and chemical information to successfully identify drug repurposing opportunities for various conditions, including Parkinson’s disease and Type 2 Diabetes.

This article discusses scalp neuropathy in androgenetic alopecia and suggests that changes in tactile sensation due to Aβ fibers and increased nociception from circ-HTMR may be involved.

This study found that neurosteroids and benzodiazepines decrease network excitability in neuronal cultures, with specific long-term depressive effects on inhibitory neurons.

This study found that deferoxamine may protect against sensorineural hearing loss by reducing oxidative stress-induced hair cell death through iron chelation and activation of the Nrf2 signaling pathway in lab models.

This study found that overexpression of Gasdermin A3 in mice disrupts the hair follicle stem cell niche and causes hair loss through cell necrosis and abnormal hair cycle progression, without involving immune-mediated mechanisms.

This letter to the editor raises concerns about minoxidil, an arterial vasodilator also used for androgenic alopecia, noting that overdose can cause severe side effects such as distributive shock, pulmonary edema, and myocardial ischemia.

This study found that full-length Agouti protein modulates melanocortin receptor signaling through a dual mechanism involving competitive antagonism and receptor down-regulation, whereas the carboxyl-terminal fragment acts solely as a competitive antagonist.

This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.

This study found that overexpression of antizyme in mice with activated MEK reduced skin tumor growth by inhibiting putrescine accumulation, slowing cell growth, and increasing G2/M transit time.

In this study using a mouse model of Pemphigus vulgaris, researchers found that loss of desmoglein 3 adhesion in hair follicle stem cells triggers a regenerative program restoring stem cell function, requiring Hedgehog pathway suppression.

This case report described how peripheral nerve stimulation provided significant pain relief and reversal of dermatological symptoms for a female patient with complex regional pain syndrome after conventional treatments failed.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential and challenges for clinical application, but it reports no new clinical findings.

This document outlines a defensive publication on restoring gap-junction-mediated morphogenetic field connectivity to address disorders of tissue function, with no new clinical results reported.

In this study, researchers developed microparticle-embedded gas-propelled microneedles that showed higher drug loading and transdermal delivery efficiency compared to traditional microneedles.

This study found that using a keratin hydrogel scaffold as a filler in collagen nerve conduits significantly improved nerve regeneration and motor recovery in Macaca fascicularis monkeys compared to saline.

In this study, researchers developed a leech-inspired microneedle platform for targeted delivery of metformin to hair follicle cells, which showed promising results in reducing inflammation and oxidative stress and promoting hair growth, offering a potential new treatment strategy for androgenetic alopecia.

This commentary reviews methods for delivering adipose-derived mesenchymal stem cell secretome for facial skin rejuvenation and does not report new clinical results; the authors discuss addressing concerns about administration methods and product characterization.

This chapter reviews pharmacodynamic evaluations in endocrine disorders focusing on oral antidiabetics, insulin analogues, and hormone interactions, but reports no new results.

This review discusses recent advances in polydopamine-based biomaterials and their growing potential in personalized medicine, but reports no new experimental results; the authors highlight both opportunities and challenges for future applications.

This study found that early mitochondrial reprogramming, specifically through fatty acid oxidation fueling oxidative phosphorylation, is crucial for initiating differentiation in epidermal stem cells, highlighting a potential therapeutic target for differentiation defects in skin disorders.

This study identified a novel phase of stem cell quiescence, GAlert, in mice, regulated by mTORC1, that primes stem cells for injury response.

Wnt signaling helps regenerate hair follicles in wounds by reducing skin cell sensitivity to mechanical stress.