Single Cell Deciphering of Pruritic Keloids: The Interaction Between Fibroblasts and Schwann Cells Through the Midkine Signaling

Schwann cell and M2 macrophage interactions contribute to keloid growth by increasing matrix deposition.

In this study, researchers conducted single-cell RNA sequencing to reveal that proinflammatory fibroblasts and vascular endothelial cells play significant roles in the immune microenvironment of keloids, suggesting potential targets for new therapeutic approaches.

Mechanical tension worsens keloid scars by activating inflammation and fibrosis pathways.

This study identified three hub genes—BMP4, POSTN, and WNT5A—that are closely associated with keloid fibroblast hyperplasia, suggesting they may serve as potential biomarkers for inhibiting this condition. Further research is necessary to fully understand their roles in keloid development.

In this study, researchers observed that intractable pruritus in anterior chest keloid lesions is linked to increased intraepidermal nerve fibre density and elevated expression of substance P, without differences in Langerhans cells across different keloid regions.