Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study reviewed the potential of Lupeol, a natural triterpenoid, in promoting hair growth and reducing inflammation related to alopecia, revealing promising molecular pathways and favorable pharmacokinetics while suggesting further research to validate these findings.

This study conducted a large-scale comparison using FAERS data to assess the post-marketing safety profiles of spironolactone, eplerenone, and finerenone, finding unique adverse event patterns for each drug and highlighting the need for personalized safety monitoring and further investigation in other pharmacovigilance databases.

This study found that repeated oral intake of 0.5 or 5 mg/kg of cobalt ferrite nanoparticles induced pulmonary toxicity in rats, with dose-dependent oxidative stress and inflammation observed, but no notable toxicity was seen at a 0.05 mg/kg dose.

This article discusses the high toxicity and potential use of thallium as a poison, highlighted by two cases of intentional thallium poisoning.

This study found that high-dose radiation can induce accelerated cellular senescence, inflammation, and loss of epithelial stem cells in mouse and human skin, contributing to radiation dermatitis.

This review discusses the challenges and contradictions in understanding nanoparticle penetration and toxicity in human skin, emphasizing the need for standardized testing and further research on particles smaller than 10 nm.

This chapter reviews studies on the side effects of cytostatics and immunosuppressive drugs, detailing various toxicities such as cardiovascular, pulmonary, and neurotoxicity, but provides no new clinical results.

This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.

This review discusses the role of nanoparticles in cancer diagnosis and treatment and outlines their potential to improve outcomes by reducing systemic toxicity and overcoming multidrug resistance, though it reports no new clinical results.

This phase II study found that gemcitabine plus paclitaxel showed promising activity and manageable toxicity as first-line therapy for recurrent or metastatic breast cancer, with a 35% overall response rate.

This study found that β-catenin stabilization in specific mammary epithelial lineages leads to cellular changes and the formation of hyperplastic lesions, revealing its role in initiating mammary neoplastic development.

This study found that caffeic acid treatment mitigated the negative effects of acrylamide toxicity in Wistar rats by normalizing tissue and serological indices.

This review discusses the molecular mechanisms by which oncogenic viruses contribute to cancer development through manipulation of host cellular functions and highlights the need for further research into virus-associated cancers, reporting no new results.

The authors concluded that pegylated liposomal doxorubicin may offer comparable efficacy to conventional doxorubicin with reduced toxicity in metastatic breast cancer treatment.

This review examines the evolving understanding of lymphatic vessel development, emphasizing new cellular mechanisms and lineage diversity, while discussing experimental methods and identifying key knowledge gaps.

This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.

This study found that in male rats, hesperidin co-administration ameliorated finasteride-induced testicular toxicity by reducing oxidative stress and improving antioxidant status, sperm parameters, and enzyme activity compared to finasteride treatment alone.

This study suggests that geranyl acetate may offer protective, anti-inflammatory, and cytoprotective effects against PPD-induced toxicity in keratinocyte cells, indicating its potential as a plant-derived treatment.

This research outlines the characteristics and potential applications of a GMP-compliant sodium polyphosphate formulation (Na-polyP-GMP) in cellular energy storage and ATP-dependent processes like skin regeneration and wound healing.

This review summarizes recent advances in nanomedicine-based therapies for psoriasis, highlighting their potential to provide targeted and sustained therapeutic effects by modulating key cellular components and signaling pathways involved in the disease, offering novel perspectives for future treatment development.

This review highlighted that targeted cancer therapies, while generally causing mild toxicities that can be managed, also pose risks of rare but serious side effects like pneumonitis and cardiotoxicities, emphasizing the need for vigilant monitoring and management to ensure patient safety.

This study found that deferiprone significantly reduced dermal fibrosis and skin thickness in mice with chronic kidney disease treated with Omniscan, suggesting iron's role in gadolinium chelate toxicity and nephrogenic systemic fibrosis.

This review discusses the mechanisms associated with protoporphyrin IX in living cells and reports no clinical results; the authors emphasize its potential in cancer diagnosis and the risks of toxicity.

This study reports that VP-16-213 (etoposide) shows significant therapeutic activity in several cancers including small cell bronchogenic carcinoma and certain leukemias, with hematologic toxicity being the primary side effect.

This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.

This review highlights the potential of near-infrared light therapy to improve metabolic, antioxidant, and cognitive functions without adverse effects, and supports its use for visual and neurological conditions through molecular and cellular mechanisms, as reported in this source.

This study found that dexamethasone-loaded Eudragit® L 100 nanoparticles displayed controlled drug release depending on pH levels, with minimal toxicity to human fibroblasts.

This review discusses the potential of repeated low-level red-light therapy to inhibit myopia progression through metabolic effects, highlighting its molecular and cellular impact, but reports no new clinical results.

This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.

This article discusses the interest in folic acid antagonists for leukemia treatment, noting their potential mechanism of interfering with cellular growth, but reports no new clinical results.