Lupeol: An Updated Review Utilizing AI-Assisted Predictive Tools for Enhanced Therapeutic Insights Into Lupeol’s Potential for Alopecia Management

September 2025 in “ Future Journal of Pharmaceutical Sciences ”

Aya M. Mustafa, Riham A. El‐Shiekh, Safaa A. Faheem, Mariam H. Fawzy, Mohamed A. Said, Ahmed F. Mohamed, Shymaa Hatem, Asmaa A. Mandour

lupeol alopecia anti-inflammatory hair growth EGFR PTGS2 hair follicle regeneration inflammation modulation bioavailability toxicity testing

TLDR Lupeol shows promise for hair growth but needs better absorption and safety testing.

The review examines lupeol's (LUP) potential for alopecia management, highlighting its anti-inflammatory and hair growth-promoting properties. AI-assisted tools reveal LUP's interaction with key protein targets and pathways, such as EGFR and PTGS2, which are crucial for hair follicle regeneration and inflammation modulation. Despite its promise, LUP faces challenges like low bioavailability and limited toxicity testing. The review suggests that future research should focus on improving LUP's bioavailability and conducting thorough safety evaluations to fully realize its therapeutic potential for alopecia.

View this study on fjps.springeropen.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

Network Pharmacology Analysis and Experimental Evaluations of YH Complex on Androgenetic Alopecia by Regulating the Androgenic-Apoptotic Axis

research Network Pharmacology Analysis and Experimental Evaluations of YH Complex on Androgenetic Alopecia by Regulating the Androgenic-Apoptotic Axis

January 2024

The YH complex, made from certain plant extracts, effectively promotes hair regrowth and could be a potential treatment for hair loss.

research Serum Epidermal Growth Factor Level and Its Relation to Severity of Alopecia Areata

1 citations , January 2024 in “International Journal of Applied Biochemistry and Molecular Biology.”

Higher EGF levels are linked to more severe alopecia areata.

Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

research Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

6 citations , January 2022 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.