Aqueous Extract of Bacopa Procumbens and the NAPEL Formulation Mitigate MPTP-Induced Neurotoxicity via Nrf2/HSF1/HIF-1α Signaling in a Parkinson’s Disease Model

    December 2025 in “ International Journal of Molecular Sciences ”
    Maribel Pérez-Rodríguez, Salvador Pérez-Mora, Marvin A. Soriano‐Ursúa, María del Consuelo Gómez-García, Yazmin M. Flores-Martínez, Juan Ocampo-López, Absalom Zamorano-Carrillo, José Manuel Viveros-Bartolomé, David Guillermo Pérez-Ishiwara
    TLDR Bacopa procumbens extract may help protect the brain in Parkinson's disease.
    This study investigates the neuroprotective effects of an aqueous extract of Bacopa procumbens and the NAPEL formulation in a mouse model of Parkinson's disease. The Bacopa procumbens extract significantly improved motor function, preserved neuronal integrity, and activated key molecular pathways (Keap1/Nrf2/ARE, HSF1, HIF-1α) associated with antioxidant defense and reduced lipid peroxidation. While NAPEL also showed behavioral and histological benefits, it did not activate these molecular pathways as effectively. The findings suggest both treatments have potential as therapeutic candidates for Parkinson's disease, with Bacopa procumbens showing particularly strong molecular activation.
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