Aqueous Extract of Bacopa Procumbens and the NAPEL Formulation Mitigate MPTP-Induced Neurotoxicity via Nrf2/HSF1/HIF-1α Signaling in a Parkinson’s Disease Model

    December 2025 in “ International Journal of Molecular Sciences ”
    Maribel Pérez-Rodríguez, Salvador Pérez-Mora, Marvin A. Soriano‐Ursúa, María del Consuelo Gómez-García, Yazmin M. Flores-Martínez, Juan Ocampo-López, Absalom Zamorano-Carrillo, José Manuel Viveros-Bartolomé, David Guillermo Pérez-Ishiwara
    Studysummary This study found that an aqueous extract of Bacopa procumbens improved motor function and preserved neuronal structure in a mouse model of Parkinson's disease, suggesting its neuroprotective potential. Our plain-language summary of this paper — not a Tressless recommendation.
    The study examines the neuroprotective effects of Bacopa procumbens extract and the NAPEL formulation in a Parkinson’s disease model induced by MPTP in mice. Bacopa procumbens extract showed significant efficacy by activating transcription factors Nrf2, HSF1, and HIF-1α, which enhance antioxidant defense and reduce oxidative damage, thus promoting neuroprotection. Although the NAPEL formulation also demonstrated neuroprotective effects, it did not activate these pathways as effectively as Bacopa procumbens. The study involved 6 groups of 6 mice each, highlighting the potential of Bacopa procumbens as a therapeutic candidate for Parkinson’s disease, though further research is needed to validate these findings.
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