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GlossaryCyclooxygenase-2 (PTGS2)

enzyme involved in inflammation and pain production

Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in the inflammatory process by converting arachidonic acid into prostaglandins, which are compounds that mediate inflammation and pain. Unlike its counterpart COX-1, which is expressed constantly in most tissues, COX-2 is typically induced during inflammation and is a target for anti-inflammatory drugs like NSAIDs (nonsteroidal anti-inflammatory drugs).

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research Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement

November 2012 in “The Journal of Urology”

Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.

research RNA Sequence Analysis of Dermal Papilla Cells’ Regeneration in 3D Culture

6 citations, October 2020 in “Journal of Cellular and Molecular Medicine”

3D culture helps maintain hair growth cells better than 2D culture and identifies key genes for potential hair loss treatments.

research After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and WNT7b to Promote Regeneration

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Double stranded RNA helps skin wounds heal by coordinating specific proteins and signaling pathways.

research Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis

4 citations, February 2018 in “Journal of Investigative Dermatology”

The document concludes that a protein involved in hair growth may link to baldness and that more research is needed on its role in hair loss and skin cancer treatments.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations, March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

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community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 3 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.