This study found that the proteins Par3, mInsc, and Gαi3 cooperate to regulate LGN polarization and promote perpendicular cell divisions during murine epidermal morphogenesis.
100 citations
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November 2017 in “EMBO Reports” This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.
This study suggests that the growth arrest of nevus melanocytes is not due to oncogene-induced senescence but rather to collective cell interactions, similar to those in normal tissue size regulation.
This study found that fibroblast growth factor 20 (Fgf20) orchestrates the movement and behavior of dermal fibroblasts, directing their formation into dermal condensates during hair follicle development in mice.
This study found that in live mouse epidermal stem cells, chromatin compaction is heterogenous and reflects differentiation status, with transcriptional changes largely preceding chromatin rearrangements during differentiation.
This study identifies Activin A and follistatin as key regulators of hair cell differentiation in the mouse auditory sensory epithelium, influencing the timing and pattern of hair cell development.
This study found that interleukin-1α and interleukin-7 secreted by keratinocytes enhance the proliferation of γδT-cells and epidermal stem cells, revealing mechanisms of stem cell activation during wound healing in mice.
This study found that super-enhancers in squamous cell carcinoma stem cells are distinctly different from those in normal skin stem cells, with ETS2 playing a crucial role in promoting tumor growth.
April 2017 in “Journal of Investigative Dermatology” This study found that hyperproliferative stimuli dysregulated the balance of stem cell divisions in keratinocytes, suggesting potential treatment strategies for both benign and cancerous hyperproliferative diseases.
June 2025 in “Cell Metabolism” This study found that dietary serine levels influence hair follicle stem cells' ability to balance hair regeneration and wound repair, offering insights for potential interventions to accelerate wound healing.
This study found that the Arabidopsis thaliana protein Formin 2 localizes to plasmodesmata and is crucial for regulating their permeability by anchoring actin filaments, which affects virus susceptibility.
This study found that Smad4 is crucial for satellite cell amplification during skeletal muscle regeneration, with aged cells exhibiting less Smad4 and reduced regenerative capability in mice.
2 citations
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July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study demonstrates that neural stem cells in the adult vertebrate brain coordinate their division decisions using delayed local feedback mechanisms, involving Notch-mediated inhibition and dispersion effects, to maintain population homeostasis.
December 2025 in “EMBO Reports” This review discusses how stem and progenitor cells communicate to synchronize their differentiation responses, highlighting the challenges in identifying these mechanisms and surveying new technologies that may overcome these obstacles.
1 citations
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December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Sox9 plays a critical role in maintaining radial glial progenitor cells and regulates the timing of their generation of upper-layer cortical neurons.
In this study, conditional inactivation of the Mad2l1 SAC gene in mice led to aggressive and lethal acute lymphoblastic leukemia and hepatocellular carcinoma, demonstrating a link between chromosomal instability and cancer development.
May 2020 in “Research Square (Research Square)” This study used cashmere goats to reveal distinct intermediate states of dermal papilla cells, each with specific roles in hair growth, shedding, and regeneration.
January 2008 in “Yearbook of Dermatology and Dermatologic Surgery” One type of progenitor cell can maintain normal skin in mice.
91 citations
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August 2014 in “Development” This review discusses how circadian clocks may influence diverse physiological functions beyond their established role in daily timekeeping, but it reports no new experimental findings.
In this study, researchers identified IL18R+ thymus-resident regulatory T cells in mice, demonstrating their unique molecular features and resistance to age- and stress-induced thymus involution, highlighting IL18 signaling's role in Treg migration and retention.
This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.
This study found that bursts of ERK activation in the epidermis of mice were linked to cell division, supporting synchronized cell proliferation and transient ERK activity in living tissues.
1 citations
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November 2024 in “Cureus” This case report describes a rare aggressive variant of squamous cell carcinoma on the scalp of a non-immunosuppressed older male, highlighting its high biological risk for metastasis and poor outcomes.
This study found that activating Hedgehog signaling in both epithelial and stromal cells can induce new hair follicles in adult mice, but this also leads to tumor formation.
In this study, upper-bulge epidermal stem cells in mouse hair follicles were shown to play a role in forming tactile sensory units by creating an extracellular matrix that supports nerve interactions.
5 citations
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May 2021 in “EMBO journal” This review discusses the role of polarity signaling in coordinating tissue mechanics, micro-environmental functions, and cell fate decisions, but it reports no new results, highlighting the need for further study in mammalian models.
April 2017 in “Journal of Investigative Dermatology” This study reports a new optimized protocol for isolating and labeling single cells from neonatal mouse skin, enabling high-quality single cell RNA sequencing for lineage-specific cell analysis.
This study suggests that Sonic hedgehog from hair follicles may support the proliferation of dentate neural stem cells in mice through transport by platelets during the perinatal period.
165 citations
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December 2004 in “Differentiation” This review discusses the critical role of BMP signaling in the development and regulation of skin and hair follicles and notes that further research could aid therapeutic advances; it presents no new clinical results.
71 citations
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November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses the role of Edar signaling in hair follicle development and cycling, emphasizing its impact on cell fate, differentiation, and interactions with other pathways, but reports no new results.