Decision Letter: Coordinated Hedgehog Signaling Induces New Hair Follicles in Adult Skin

May 2019

Hedgehog signaling hair follicles Gli1creERT2 Ptch1 basal cell carcinoma hair growth phases tumor development Hh signaling BCC

Studysummary This study found that activating Hedgehog signaling in both epithelial and stromal cells can induce new hair follicles in adult mice, but this also leads to tumor formation.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

Read the full study on elifesciences.org →

Discuss this study in the Community →

Similar research 5

Author Response: Coordinated Hedgehog Signaling Induces New Hair Follicles in Adult Skin 2019
Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000
Single Molecule FISH for Hedgehog Signaling in Mouse Skin The journal of investigative dermatology/Journal of investigative dermatology · 2016
Modulation of Sonic Hedgehog, Patched and Patched-2 Expression by Epidermal Growth Factor Signaling in Mouse Hair Follicle Formation Medical Entomology and Zoology · 2000

Related Community Posts Join

6 / 1000+ results

community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community Hair Multiplication Projects in China - Promising clinical trial results on Mice

34 upvotes 1 year ago

A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.

community Korean scientists breakthrough in hair regeneration targeting CXXC5 protein and WNT Signaling Pathway

53 upvotes 8 years ago

A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.

community Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling

23 upvotes 11 months ago

Fatty acid metabolic signaling can activate epithelial stem cells for hair regeneration. Oleic and palmitoleic acids showed the best results, but practical application on humans remains uncertain.

community Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

4 upvotes 11 years ago

Hair follicle regeneration through stem cell rearrangement is discussed, focusing on bioengineered cellular structures rather than traditional hair transplants. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Expectations control for SCUBE3

20 upvotes 2 years ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.