April 2013 in “Cancer Research” This study confirmed the presence of specific stem cell populations in SKH1 hairless mice skin, including CD34+/α6-integrin+ cells, which are important for investigating ultraviolet radiation-induced carcinogenesis.
31 citations
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February 2014 in “Inflammation Research” This study found that reduced expression of CD200R1 on monocyte-derived macrophages in rheumatoid arthritis patients was significantly associated with higher disease severity and an imbalance in Th17/Treg cells.
13 citations
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October 2020 in “Journal of Neural Transmission” In this study, CD34-positive progenitor cells in irradiated salivary glands were observed to potentially aid in blood vessel formation and remodeling, suggesting their role in tissue healing after radiotherapy.
23 citations
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July 2023 in “Proceedings of the National Academy of Sciences” In this study using a mouse model and human data, researchers found that CD8+ T cells are central to driving alopecia areata, while regulatory T cells offer some protection, highlighting CD8+ T cells as key targets for future therapy development.
3 citations
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October 1994 in “Journal of Dermatological Science” This study developed a novel monoclonal antibody, TYHF-1, which specifically reacts with hair keratins but not with epidermal keratins or various other tissue cells.
September 2016 in “Journal of Dermatological Science” This study found that plasmacytoid dendritic cells may initiate alopecia areata in mice by overexpressing interferon-alpha.
April 2023 in “Cancer research” This study suggests that KRTAP2-3 may serve as a novel biomarker to identify cells in the polyaneuploid cancer cell state, which is linked to therapy resistance and poor prognosis in prostate cancer.
157 citations
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October 2002 in “Journal of Cutaneous Pathology” This study suggests that p63 is consistently expressed in the basal cells of the skin and may influence differentiation and the development of common skin carcinomas.
This study found that neutrophil-rich hair follicle inflammation caused by a monoclonal antibody targeting murine EGFR in mice involved TNFα and interleukin-1, suggesting these cytokines play a role in EGFR antibody-induced rashes in cancer patients.
4 citations
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June 2025 in “Cell Reports” In this study using the C3H/HeJ mouse model of alopecia areata, researchers found that hyperexpanded CD8+ T cell clones were sufficient to initiate disease, establishing a causal link between T cell clonality and pathogenicity.
April 2018 in “Journal of Investigative Dermatology” This study found that DC-HIL+ myeloid derived suppressor cells are increased in the blood and skin of patients with cutaneous lupus erythematosus and show immunosuppressive properties.
This study investigated dual TCR Treg cells in mouse tissues, revealing a high proportion and diverse pairing patterns compared to single TCR Tregs, providing insights into their origins and characteristics across different tissue locations.
April 2022 in “Research Square (Research Square)” This study established the R-7 dermal papilla cell line, which retained essential characteristics of primary cells without undergoing malignant transformation, suggesting its potential for future hair research.
April 2019 in “Journal of Investigative Dermatology” This study developed an Asian human sebocyte cell line from breast skin tissue that can be used for sebaceous gland biology investigations, showing that Y27632 may promote cell growth through EGFR-CRAF-MEK-ERK and AKT pathways.
February 2020 in “Definitions” This article discusses the human KRT72 wild-type allele's role in hair formation and reports no new research findings.
3 citations
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April 2012 in “Cancer research” This study reports that side-population stem cells, distinct from hair follicle stem cells, may play a significant role in the malignant progression of squamous cell carcinomas in mice.
This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.
99 citations
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April 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that human hair follicles serve as a crucial reservoir for Langerhans cells, which repopulate the epidermis depleted by ultraviolet B exposure.
This study in mice found that a monoclonal antibody targeting EGFR resulted in skin inflammation mediated by TNFα, suggesting potential pathways for addressing EGFR antibody-induced skin rash in cancer patients.
1 citations
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April 2016 in “Journal of Investigative Dermatology” This study suggests that NKG2D+ Vδ1 T cells may contribute to hair follicle pathology in alopecia areata by recognizing stressed keratinocytes and inducing immune privilege collapse.
60 citations
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October 2020 in “Nature Communications” This study found that small molecule AP-1 inhibitors may selectively target SMO inhibitor-resistant basal cell carcinoma cells characterized by specific markers, potentially enhancing combinatorial cancer therapies.
March 2011 in “Journal of Dermatology” This figure in the publication investigates the relationship between expression levels and tumor burden but reports no specific findings or conclusions.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that p21 is much more highly expressed in normal melanocytes compared to melanoma cells, suggesting a potential target for preventing melanoma progression through cell cycle repair processes.
23 citations
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June 2015 in “Oncology Letters” This study reported that adipose-derived stem cell-conditioned medium demonstrated anti-tumorigenic effects on B16 melanoma cells both in vitro and in vivo, indicating potential for future melanoma treatment.
11 citations
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September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.
July 2019 in “Tumor Biology” In this study, researchers found that bone marrow-derived epithelial cells significantly contribute to the development of cutaneous tumors and dysplastic ulcers in mice, indicating a potential systemic role in skin cancer development.
April 2023 in “Authorea (Authorea)” This case report describes the presentation of a 32-year-old Iranian immunocompetent female diagnosed with Merkel Cell Carcinoma, highlighting the importance of early diagnosis and management to mitigate complications.
July 2025 in “Journal of Investigative Dermatology” Enhancing Tregs can protect against alopecia areata.
January 2024 in “Wiadomości Lekarskie” This study outlines new strategies for overcoming "cold" tumors, which are typically unresponsive to cancer immunotherapy, with approaches like dendritic cell-based treatments and local immune microenvironment modification, bolstered by both preclinical and clinical trial data.
13 citations
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August 2017 in “Journal of Cellular Physiology” In this study, researchers found that in mouse models of alopecia areata, the expression of immune-regulating molecules PD-L1 and PD-L2 in dermal fibroblasts is increased by activated T cells, potentially indicating a lack of negative immune control in affected skin.