ScRNA+TCR-Seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-Lymphoid Tissues
July 2025
TLDR Dual TCR Treg cells are common in mouse tissues and vary by location.
This study utilized scRNA+TCR-seq technology to analyze over 5,000 T cells per sample, revealing a high proportion of dual TCR Treg cells in various mouse tissues, including lymphoid and non-lymphoid sites. The research highlighted both similarities and differences in TCR pairing patterns, V(D)J usage, and mRNA expression between dual and single TCR Tregs, as well as heterogeneity across different tissue locations. These findings offer new insights into the origins, characteristics, and mechanisms of Treg cells, enhancing our understanding of their roles in different tissue environments.
