Single-Cell RNA and TCR Sequencing Reveals the Proportion and Characteristics of Dual TCR Regulatory T Cells in Mouse Lymphoid and Non-Lymphoid Tissues
December 2024
Studysummary In this study, researchers analyzed over 5,000 T cells per sample using scRNA+TCR-seq technology and found that dual TCR Tregs are present in high proportions across various mouse tissues, showing unique TCR pairing patterns, V(D)J usage, and mRNA expression compared to single TCR Tregs.
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