KRTAP 2-3 as a Novel Potential Biomarker of Cells in the Polyaneuploid Cancer Cell State to Predict Cancer Recurrence

    April 2023 in “ Cancer research ”
    Sabrina A. Mendez, Reema Sharma, Kenneth J. Pienta, Sarah R. Amend
    TLDR KRTAP2-3 could help predict cancer recurrence by identifying specific cancer cells.
    Researchers have identified the Keratin Associated Protein 2-3 (KRTAP2-3) as a potential biomarker for cells in the polyaneuploid cancer cell (PACC) state, which is linked to therapy resistance and cancer recurrence in prostate cancer (PCa). The study found that KRTAP2-3 is highly expressed in PACC state cells but not in most normal tissues, making it a promising marker. Using RNA in situ-hybridization (RNAish), KRTAP2-3 successfully distinguished PACC state cells with 96% accuracy. This discovery could lead to better prognostic tools for predicting cancer recurrence in PCa patients.
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