Data from Tumor Necrosis Factor-Alpha and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

March 2023

David Surguladze, Dhanvanthri S. Deevi, Nidia Claros, Erik Corcoran, Su Wang, Mary Jane Plym, Yan Wu, Jacqueline Doody, David J. Mauro, Larry Witte, Klaus J. Busam, Bronek Pytowski, Ulrich Rodeck, James R. Tonra

epidermal growth factor receptor EGFR tumor necrosis factor-α TNFα interleukin-1 monoclonal antibody ME1 neutrophil-rich inflammation hair follicles etanercept Kineret cytokines IL-1 Enbrel anakinra

TLDR TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.

The study investigates the inflammatory skin changes caused by epidermal growth factor receptor (EGFR) antibody therapy, specifically using a monoclonal antibody, ME1, in mice. This therapy led to neutrophil-rich hair follicle inflammation and lipid-filled hair follicle distensions. The cytokine tumor necrosis factor-α (TNFα) was found to be up-regulated in the affected skin regions, and its involvement in the inflammatory process was confirmed by the reduction of inflammation through the TNFα inhibitor, etanercept. Additionally, the interleukin-1 antagonist Kineret also alleviated the inflammation, suggesting that both TNFα and interleukin-1 play roles in this condition. The findings provide a basis for developing evidence-based treatments for EGFR antibody-induced skin rashes in cancer patients.

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