research Ligand-Independent Actions of Vitamin D Receptor
The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.
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690-720 / 1000+ results research Noncalcemic Actions of 1,25-Dihydroxyvitamin D3 and Clinical Applications
Vitamin D3 is important for bone health and may help treat various diseases beyond bone-related conditions.
research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair
The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.
research Levetiracetam in the Treatment of Idiopathic Generalized Epilepsies
Levetiracetam is widely used and generally well-tolerated for treating idiopathic generalized epilepsies, with tiredness as the main side effect.
research Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death
The study used zebrafish to investigate drug-induced hair cell death and identify protective agents. Zebrafish were ideal due to their genetic similarities to mammals and external hair cells. Researchers found three zebrafish mutants resistant to neomycin-induced hair cell death, involving genes not previously linked to hair cell toxicity. They screened 10,960 compounds, identifying several protective agents, including FDA-approved drugs. The study revealed that many protective compounds did not affect the bactericidal activity of aminoglycosides, except Benzamil. Selective estrogen receptor modulators were effective against neomycin exposure. The research highlighted disrupted calcium homeostasis as a mechanism of hair cell toxicity, with calcium release from the endoplasmic reticulum causing mitochondrial dysfunction and increased reactive oxygen species. The zebrafish model was effective in understanding hair cell death mechanisms and identifying potential treatments for hearing loss and balance disorders.
research The Role of Pannexin 3 in Bone Biology
Pannexin 3 is important for bone formation and the development of bone cells.
research Drug-Induced Hair Color Changes
Some medications can change hair color, especially chloroquine and cancer treatments.
research Effects of cepharanthine and minoxidil on proliferation, differentiation and keratinization of cultured cells from the murine hair apparatus
The study examined the effects of cepharanthine and minoxidil on cultured cells from the murine hair apparatus, focusing on cell proliferation, differentiation, and keratinization. Both compounds stimulated cell proliferation and delayed differentiation and keratinization. By day 6, most control cells had differentiated, while cells treated with cepharanthine (71%) or minoxidil (70%) remained immature. By day 13, cell degeneration was minimal in treated cultures compared to controls. Keratinization was induced by elevated calcium in control cultures but was absent in treated cultures until day 13, when it occurred in cepharanthine (30%) and minoxidil (48%) cultures. The results indicated that cepharanthine and minoxidil directly influenced these cellular processes.
research Calcipotriol Scalp Solution in the Treatment of Scalp Psoriasis: Comparative Efficacy with Coal Tar/Coconut Oil/Salicylic Acid Shampoo and Long-Term Experience
Calcipotriol scalp solution works better than coal tar shampoo for treating scalp psoriasis and is safe for long-term use.
research Diabetex: A Novel Approach for Diabetic Wound Healing
Diabetex improves diabetic wound healing better than metformin.
research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts
Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.
research Possible Relationship Between Chronic Telogen Effluvium and Changes in Lead, Cadmium, Zinc, and Iron Total Blood Levels in Females: A Case-Control Study
Higher lead and cadmium, and lower zinc and iron levels in the blood might be linked to chronic hair loss in women.
research Nongenomic Effects of 1α,25-Dihydroxyvitamin D3 on Cartilage Formation Deduced from Comparisons Between Cyp27b1 and Vdr Knockout Mice
1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.
research Parathyroid Hormone Linked to a Collagen Binding Domain Promotes Hair Growth in a Mouse Model of Chemotherapy-Induced Alopecia in a Dose-Dependent Manner
A hormone linked to collagen helps hair grow back in mice after chemotherapy, and may also prevent bone loss.
research Vitamin D Resistance and Alopecia
Vitamin D is important for more than just bone health.
research Hypertension: Sex-Related Differences in Drug Treatment, Prevalence and Blood Pressure Control in Primary Care
Women experience more side effects and have worse blood pressure control from hypertension treatments than men, despite using different medications.
research Basic Nutrition for Sports Participation, Part 2: Vitamins and Minerals
Athletes usually get enough vitamins and minerals from a healthy diet, and supplements are only needed for those with actual deficiencies.
research Beneficial Uses of Breadfruit (Artocarpus Altilis)
Breadfruit is nutritious and has potential health and medicinal benefits, but is currently underused.
research Antioxidants and Long Covid
Antioxidants might help manage Long Covid by addressing oxidative stress and nutrient imbalances.
research Effects of Roasting Periods on the Nutritive Value of Telfaira Occidentalis (Fluted Pumpkin) Seeds
Roasting fluted pumpkin seeds for 60 minutes increases their protein content and makes them better as a food supplement.
research An Effective New Therapy for Burn Wounds
New therapies for burn wounds show promise in reducing pain, infection risk, and improving healing and physical outcomes.
research A Case of a 50-Year-Old Female With Dermatomyositis Secondary to a Paraneoplasm (Infiltrating Ductal Carcinoma, Grade 2)
A 50-year-old woman with breast cancer developed an autoimmune skin disorder, highlighting the need for thorough checks and team-based treatment.
research Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects
Isotretinoin affects trace element levels and requires monitoring of liver and kidney functions.
research An Unusual Case of Diarrhea, Dysgeusia, and Grainy and Nodular Mucosa
A 78-year-old man with Cronkhite-Canada syndrome improved significantly after treatment and remains symptom-free.
research Not Always 'Straight Ahead' – A Surprising Cause of Acute Kidney Injury
Hair straightening treatments can cause serious kidney damage, especially if you have skin issues.
research Effect of Vitamin D Supplementation on Ovulation Induction Among Women with Polycystic Ovary Syndrome
Taking Vitamin D with clomiphene citrate significantly improves ovulation in women with Poly Cystic Ovary Syndrome.
research Hypothyroidism with Multiple Associations: Case Report
The patient with autoimmune hypothyroidism improved after treatment for thyroid and associated conditions.
research Obituary: Professor Edward Carmeliet 1930 – 2021
Professor Edward Carmeliet was a leading figure in cardiac electrophysiology research.
research Mutamba Fruits (Guazuma Ulmifolia Lam.) - Physical, Physicochemical, and Antioxidant Characterization
Mutamba fruits are rich in soluble solids, vitamin C, and minerals, making them good for food industry use.
research Nutritional Skin Diseases in Goats
Some goats get rare skin diseases from not enough vitamin E, selenium, or zinc, but they're usually still healthy.