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Spironolactone plus finasteride reduces hirsutism more effectively.

Progesterone boosts alcohol's effect on brain, finasteride counters it.

Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Finasteride reduces new brain cells in male mice, possibly causing depression.

Spironolactone is better than placebo for reducing excessive hair growth in women, but its effectiveness for acne is unclear due to small study sizes.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Late pregnancy helps repair brain damage in rats due to the GABAergic system.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Finasteride reduces alcohol withdrawal effects, especially in female mice.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Spironolactone did not make hair thinner in women with excess hair growth.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Aldactone was more effective in reducing hair growth in women with hirsutism than Diane, despite having less impact on hormone levels.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Women experience various skin issues at different life stages, requiring careful treatment and awareness.

Genetic counselors should be culturally skilled and aware of transgender patients' unique health risks and needs.

The document concludes that treatments for female hair loss and excessive hair growth are temporary and not well-studied.

Certain hair straighteners and dyes may increase ovarian cancer risk, especially in African American/Black women.