277 citations
,
July 2002 in “Molecular Endocrinology” In this study, homozygous VDR null mutant mice exhibited nonfunctional vitamin D receptors, leading to growth abnormalities and revealing the limited physiological importance of vitamin D pathways outside the classical receptor.
240 citations
,
February 2005 in “Diabetes Care” This review discusses the nutritional and metabolic problems following bariatric surgery, emphasizing the need for ongoing monitoring and treatment, but reports no new clinical results.
166 citations
,
October 2018 in “Endocrine Reviews” This review discusses the effects of hormonal treatments on the physical and mental health of transgender individuals, reporting significant reductions in mental health issues following treatment, but calls for more research on long-term and nonbinary outcomes.
151 citations
,
June 2010 in “Endocrinology and metabolism clinics of North America” This article compares two rare genetic diseases, vitamin D-dependent rickets type 1 and type 2, focusing on their similar presentations of hypocalcemia and rickets in infancy, but reports no new clinical results.
72 citations
,
October 1998 in “Baillière's clinical endocrinology and metabolism” This article discusses the potential effects of exogenous testosterone, highlighting that its impact on prostate cancer progression, cardiovascular health, and behavior remains uncertain and needs further investigation.
70 citations
,
August 2020 in “Nanomaterials” This review discusses the development of electrospun nanofibrous scaffolds for promoting angiogenesis in tissue engineering but notes that their clinical application beyond bone and skin repair is still limited.
65 citations
,
April 2000 in “The Laryngoscope” This study concluded that clotrimazole, miconazole, and tolnaftate appeared safe in guinea pigs, whereas gentian violet showed potential for severe ototoxicity, and nystatin left a concerning residue.
51 citations
,
April 1999 in “The Journal of Steroid Biochemistry and Molecular Biology” This review examines androgen replacement therapy in women for treating androgen deficiency symptoms and reports no new clinical results, while noting potential safety within a specific dose range.
50 citations
,
January 2016 in “The FEBS journal” This review discusses the various roles of RANK signaling in bone remodeling, immune function, and epithelial differentiation, highlighting its potential involvement in cancer mechanisms; it reports no new clinical results.
49 citations
,
February 2008 in “Stem Cells” This study found that after injury, the bone marrow microenvironment's increased Wnt10b expression supports hematopoietic stem cell regeneration by enhancing Wnt signaling, revealing a vital interaction during recovery.
49 citations
,
January 2006 in “Developmental Dynamics” This research observed that the skeletal abnormalities in Noggin null mice varied based on genetic background, and identified haploinsufficiency leading to joint fusions, similar to human conditions associated with NOGGIN deficiency.
44 citations
,
September 1948 in “Radiology” This article reports that hypervitaminosis A in both experimental rats and children leads to severe symptoms such as weight loss, bone issues, and skin problems, which resolve upon stopping vitamin A intake.
42 citations
,
December 2016 in “Cell Death & Differentiation” This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.
42 citations
,
May 2007 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism” In this animal study, administering testosterone alongside a 5α-reductase inhibitor counteracted testosterone's effects on prostate enlargement while preserving its beneficial effects on muscle and bone.
37 citations
,
June 2011 in “Journal of Cellular Biochemistry” In this study, transgenic male mice over-expressing the androgen receptor in mesenchymal stem cells showed reduced fat mass and improved glucose clearance, suggesting enhanced androgen sensitivity may alter body composition.
31 citations
,
June 2017 in “Regeneration” This study found that applying BMP2 stimulated limited regeneration of the amputated P2 bone in mice, but only when applied during a specific "regeneration window" after injury.
31 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.
29 citations
,
April 2020 in “Biomolecules” The study suggests that a 3D culture system using the RAD16-I peptide scaffold can help restore the original phenotype of hair follicle dermal papilla cells and support their osteogenic and adipogenic differentiation.
17 citations
,
May 2013 in “Oral and Maxillofacial Surgery Clinics of North America” This article reviews the complex challenges of managing scalp and cranial deformities post-trauma or surgery, advocating for better multidisciplinary approaches to enhance outcomes, but reports no new results.
10 citations
,
August 2023 in “Advanced Science” This review discusses nitric oxide's physiological roles and the development of strategies for delivering it exogenously, without presenting new clinical results.
10 citations
,
May 2021 in “Stem Cell Research & Therapy” In this study, subcutaneous injection of bone marrow mesenchymal stem cells in burned rats significantly improved wound healing by reducing inflammation, scar formation, and wound size, and restoring normal skin structures.
9 citations
,
April 2021 in “Evidence-based complementary and alternative medicine” This study found that Guilu Erxian Glue significantly alleviates various doxorubicin-induced side effects in mice, enhancing exercise capacity and reducing oxidative stress and inflammation.
7 citations
,
January 2023 in “Frontiers in Cell and Developmental Biology” This review provides a comprehensive overview of apoptosis-related molecules in head development, highlighting caspases' roles and associated abnormalities in tissues like the brain, sensory organs, skin, and bones, without reporting new results.
5 citations
,
August 2020 in “Stem Cell Research & Therapy” This study found that combining adipose-derived mesenchymal stromal cells with meglumine antimoniate reduced lesion size and parasite load in mice with leishmaniasis, suggesting potential for improved treatment.
5 citations
,
December 2014 in “Polish Journal of Public Health” This review discusses the mechanisms of zinc transport, its role in human health, and the effects of zinc imbalance, without reporting new results.
4 citations
,
August 2023 in “Varna Medical Forum” This article explores the therapeutic potential of TECAR therapy for physiotherapy, highlighting its non-invasive nature and ability to provide analgesic, anti-inflammatory, and tissue healing effects across various conditions with minimal side effects when applied correctly.
4 citations
,
June 2023 in “Journal of developmental biology” In this study, researchers propose that different vertebrate skin appendages, such as hair, feathers, and scales, evolved in parallel from a shared ancestral cell structure associated with teeth, dating back approximately 420 million years ago.
4 citations
,
September 2021 in “Biomolecules” This review examines experimental studies on the synergistic use of platelet-rich plasma and adipose-derived mesenchymal stem cells for wound healing in animal models, without reporting new clinical outcomes.
4 citations
,
January 2017 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” This study identified two distinct VDR gene mutations among Lebanese families with hereditary vitamin D-resistant rickets, noting varied treatment responses and promising outcomes despite severe phenotypes.
4 citations
,
May 2007 in “Oral and Maxillofacial Surgery Clinics of North America” This article reviews gender differences in planning and managing female cosmetic surgery patients and reports no new clinical findings.