10 citations
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December 2001 in “PubMed” This research suggests that both proposed pathways into hair fibers for molecule penetration are valid and complementary, with all fiber structures acting as potential routes for delivering materials.
69 citations
,
January 2002 in “Journal of biomedical optics” This study found that commercially available dyes penetrate up to 1.2 mm into human skin, with Indocyanine Green binding to cell proteins and showing a shift in absorption peak.
48 citations
,
April 2019 in “ACS Applied Materials & Interfaces” In this study, researchers introduced calcium carbonate-based carriers for transdermal drug delivery, observing efficient transport of substances and systemic absorption in rats, suggesting potential applications in regenerative medicine and dermatology beyond conventional topical treatments.
April 2023 in “Advanced functional materials” This study created a Wnt3a protein gradient using Multiphoton Microfabrication technology, which improved hair-inductive properties in mouse and human hair dermal papilla cells, suggesting potential applications in hair regeneration research and drug screening.
This study found that Biofield Energy Healing Treatment significantly increased the proliferation of human hair follicle dermal papilla cells in vitro, suggesting potential as a hair growth enhancer.
67 citations
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May 2013 in “Therapeutic drug monitoring” This study explores the complexities of interpreting single drug exposure in hair, emphasizing factors like drug distribution variability and suggests methods to validate single exposure findings in forensic cases.
January 2026 in “Elsevier eBooks” 3 citations
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November 2024 in “International Journal of Pharmaceutics” Larger positively charged gelatin nanoparticles are more effective for delivering treatments to hair follicles.
13 citations
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January 2021 in “Histochemistry and Cell Biology” In this study, human hair follicles showed varying expression of cholesterol transport proteins during the hair cycle, suggesting a potential role of cholesterol in hair growth and cycling.
May 2026 in “Journal of Health Sciences and Medicine” This study found that biotinoyl tripeptide-1-loaded solid lipid nanoparticles significantly improved thermal protection in hair, enhancing cuticle integrity and resistance to heat damage, compared to control samples.
64 citations
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March 2005 in “Journal of Investigative Dermatology” This study found that brain-derived neurotrophic factor (BDNF) inhibited hair shaft elongation and induced premature catagen development in cultured human hair follicles, partially through transforming growth factor β2.
7 citations
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October 2024 in “Drug Delivery and Translational Research” In this study, using an ex vivo porcine skin model, researchers found that a 4% nanoparticle concentration significantly enhanced the transport of fluorescein sodium into hair follicles compared to a 2% concentration, while higher concentrations did not further increase penetration depth.
1 citations
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January 2014 This review discusses various methods to assess bioequivalence between dermatologic drugs and highlights the potential of visual inspection and percutaneous penetration research.
15 citations
,
February 2013 in “Pharmaceutical nanotechnology” This study found that invasomes enhanced the iontophoretic transdermal delivery of finasteride in rabbits, increasing AUC and T1/2 compared to oral suspension.
34 citations
,
July 1958 in “Biochimica et Biophysica Acta” 161 citations
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April 2006 in “Journal of Investigative Dermatology” Liposomes with certain properties can effectively deliver drugs deep into hair follicles.
October 2025 in “Phytochemistry Letters” 4 citations
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July 2023 in “Analytical and Bioanalytical Chemistry” December 2018 in “Zenodo (CERN European Organization for Nuclear Research)” This study observed that Biofield Energy Treated William’s Medium E increased telogen follicle formation in vibrissae hair follicle culture cells, suggesting potential hair growth promotion.
April 2016 in “CRC Press eBooks” This chapter reviews the potential applications of genetic engineering in hair growth research and development but provides no new experimental results, emphasizing the need for innovative approaches in the field.
May 2026 in “Preprints.org” This study found that a supplement containing cystine, B vitamins, and minerals improved hair condition in 34 women with diffuse hair loss over six months, as evidenced by an increased anagen/telogen hair ratio, positive participant feedback, and no serious side effects.
37 citations
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January 1997 in “Journal of Pharmaceutical Sciences” This study observed that hairless rat skin was more permeable to mannitol and progesterone than hairy rat skin, indicating that follicular structures significantly impact percutaneous absorption.
In this study, Biosea® Revive serum, containing biotinoyl tripeptide-1 and Phyllanthus emblica extract, was found to improve hair density and quality in a 90-day clinical trial without adverse effects, offering a potential natural solution for hair growth.
22 citations
,
January 1968 in “THE JOURNAL OF VITAMINOLOGY” This study found that α-tocopheryl acetate is well absorbed through healthy skin, with absorption occurring through specific pathways and showing high affinity for small blood vessels.
6 citations
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November 2019 in “Journal of Cosmetic Dermatology” This study found that applying a 1% BOI lotion improved hair density and thickness in patients with mild pattern hair loss over six months.
In this study, Biofield Energy Healing significantly increased the proliferation of human hair follicle dermal papilla cells in vitro, suggesting potential as a hair growth promoter.
122 citations
,
March 2013 in “Expert opinion on drug delivery” This review summarizes drug delivery strategies to hair follicles, highlighting physicochemical factors affecting penetration and the use of stimuli-responsive particulate carriers, but reports no new clinical findings.
2 citations
,
August 2020 in “Chemical and Pharmaceutical Bulletin” This study found that rubbing increased caffeine permeation into skin primarily via hair follicles, especially when applied against the natural hair direction.
2 citations
,
November 1961 in “American Journal of Clinical Nutrition” 49 citations
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November 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that 1,25-dihydroxyvitamin D3/VDR inhibits β-catenin's role in keratinocyte proliferation but enhances its role in hair follicle differentiation.