January 2025 in “JAAD Case Reports” In this study, researchers noted that while Poly-L-lactic acid dermal fillers boost collagen synthesis to add volume and reduce wrinkles, there is no established link between these fillers and hair loss according to existing literature.
November 2025 in “Scientia Pharmaceutica” This review highlights that injectable biostimulatory agents like poly-L-lactic acid, polycaprolactone, and calcium hydroxyapatite are effective in regenerative aesthetics by enhancing collagen production, stimulating adipogenesis, and improving dermal quality, although further research is needed to standardize protocols and confirm long-term safety and efficacy.
May 2026 in “Journal of Cosmetic Dermatology” This narrative review found that skin boosters, including hyaluronic acid and other agents, improve skin hydration, elasticity, and texture with favorable safety, though evidence is limited by study heterogeneity and lacks standardized protocols, suggesting a need for further clinical research.
January 2026 in “Journal of Aesthetic Nursing” This review discusses the regenerative potential of polynucleotides and polydeoxyribonucleotides in aesthetic medicine, noting their benefits for skin texture, hydration, and patient satisfaction despite limited high-quality evidence.
This study concluded that using Plasma gel and PRP as autologous collagen biostimulators improved acne scars and skin density, demonstrating efficiency and safety for facial rejuvenation in clinical evaluations including patient satisfaction.
February 2025 in “Brazilian Journal of Hair Health” This study found that multiparametric ultrasound effectively detects real-time scalp changes caused by vasoconstrictive cosmetic agents, demonstrating its potential as a non-invasive tool for evaluating trichological treatments.
14 citations
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August 2020 in “Journal of cosmetic dermatology” This consensus report provides detailed recommendations for using Polynucleotides Highly Purified Technology™ in aesthetic skin rejuvenation, highlighting its potential as a biostimulatory booster for face and body revitalization.
2 citations
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March 2021 in “Carpathian Journal of Food Science and Technology” This review discusses the medicinal and health benefits of caraway, Chinese chives, and cassia, focusing on their antibacterial, antioxidant, antimicrobial, anti-inflammatory, and anticancer properties due to their range of secondary metabolites.
2 citations
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March 2025 in “Otolaryngologic Clinics of North America” Nonsurgical facial treatments are becoming more popular due to their natural-looking results and minimal invasiveness.
December 2024 in “Health Science Reports” This review found that topical metformin shows potential as a treatment in dentistry for periodontitis and in dermatology for conditions like wound healing and acne, but results for melasma are inconsistent.
January 2026 in “Dermatologic Therapy” This review indicates that while microneedling shows potential for managing androgenetic alopecia, particularly in combination with other treatments, the existing evidence is of low to moderate quality, and more robust trials are needed to confirm its clinical efficacy and safety.
June 2026 in “WORLD JOURNAL OF PLASTIC SURGERY” This study highlights that modern facial rejuvenation techniques have shifted toward minimally invasive injectable methods, with botulinum toxin and hyaluronic acid fillers effectively reducing wrinkles, enhancing facial features, and temporarily addressing age-related facial changes as alternatives to more invasive surgery.
January 2026 in “Clinical Cosmetic and Investigational Dermatology” This expert opinion article presents insights from dermatologists and aesthetic physicians on using polynucleotides (Rejuran®) for skin hydration, rejuvenation, structural support, barrier repair, and scar remodeling, noting their favorable safety profile but highlighting the need for more robust evidence and research.
December 2025 in “Aesthetic Plastic Surgery” This study reported that the new near-infrared LED device showed significant improvements in skin rejuvenation and a slight increase in hair growth, with further research recommended for broader validation.
1 citations
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September 2025 in “Dermatology and Therapy” This review suggests that glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have potential benefits for dermatologic conditions but may also cause adverse skin reactions and impact surgical outcomes.
February 2026 in “Plastic and Aesthetic Research” This narrative review examines advancements in regenerative aesthetic medicine, focusing on injectable modalities like PRP, polynucleotides, and exosomes, but highlights the need for more robust evidence and standardization in clinical applications.
1057 citations
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November 2011 in “Annals of Biomedical Engineering” This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.
81 citations
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July 2011 in “Lasers in Medical Science” This study found that using a low-level laser comb led to hair regrowth in a mouse model of alopecia areata, while sham-treated mice showed no hair regrowth.
38 citations
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January 2023 in “International Journal of Medical Sciences” This review discusses the potential of repeated low-level red-light therapy to inhibit myopia progression through metabolic effects, highlighting its molecular and cellular impact, but reports no new clinical results.
22 citations
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July 2024 in “Archives of Plastic Surgery” This review detailed the types and mechanisms of injectable "skin boosters" and evaluated their effectiveness and safety for mitigating age-related skin changes, providing insight into their use in contemporary dermatological practice.
12 citations
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October 2012 in “Dermatologic Clinics” This review discusses the use of electromagnetic radiation, including low-level laser therapy, for hair loss management, but it reports no new clinical results and suggests further research.
10 citations
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August 2020 in “Indian Journal of Plastic Surgery/Indian journal of plastic surgery” This minireview discusses the mechanisms of facial aging, examines current literature, and proposes filler injection protocols, but it reports no new clinical results.
1 citations
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July 2020 in “Dermatology” This review discusses the mechanisms, applications, and research evidence of photobiomodulation, highlighting its efficacy, safety, and potential for standardized evaluation methods, but reports no new clinical results.
April 2026 in “Nowotwory Journal of Oncology” This review provides a clinical guide for safely using dermo-aesthetic treatments to improve the quality of life for oncology patients dealing with treatment-related side effects, emphasizing the importance of consulting with an oncologist before undergoing such procedures.
March 2026 in “Voprosy dermatologii i venerologii/Dermatologiâ ža̋ne veneralogiâ ma̋selelerì” In this article, the authors describe a successfully treated case of a newborn with ichthyosis using a neonatal protocol involving an incubator with controlled temperature and humidity, sepsis prevention, eye protection, and emollient care without keratolytics during the early neonatal period.
March 2026 in “Voprosy dermatologii i venerologii/Dermatologiâ ža̋ne veneralogiâ ma̋selelerì” This study discusses how polynucleotide-based cosmetic products can improve aging skin in patients with particular morphotypes by restoring cellular metabolism, enhancing microcirculation, and promoting intracellular matrix remodeling, offering potential benefits for reversing chrono- and photo-aging and aiding tissue recovery after cosmetic or surgical procedures.
March 2026 in “Voprosy dermatologii i venerologii/Dermatologiâ ža̋ne veneralogiâ ma̋selelerì” This study highlights the underexplored allergenic potential of Trichophyton rubrum, a dermatophyte, which can trigger IgE-mediated allergic reactions and a Th2 immune response shift, underscoring the need for its inclusion in diagnostic panels and further research for treating chronic mycoses and related allergies.
March 2026 in “Voprosy dermatologii i venerologii/Dermatologiâ ža̋ne veneralogiâ ma̋selelerì” This study conducted among sex workers in Kostanay reported a low HIV prevalence of 0.8% but a high syphilis rate of 15.6%, highlighting significant social risks and emphasizing the need to expand pre-exposure prophylaxis and prevention programs.
September 2025 in “Cureus” This narrative review highlights recent advancements in anti-ageing cosmetic procedures, emphasizing personalized interventions that improve patient outcomes and quality of life. The review synthesized evidence from 144 articles to assess the effectiveness and potential side effects of surgical and non-surgical techniques for facial rejuvenation.
June 2022 in “Al-Qadisiyah Journal of Veterinary Medicine Sciences” This study found that 660 nm laser treatment and povidone iodine both eradicated Pseudomonas aeruginosa infection in mice wounds, with the laser enhancing healing, and the combination provided additive or synergistic healing benefits.