Role of Dermatophytes in the Formation of Organism Sensitization
TLDR Dermatophytes, like Trichophyton rubrum, can cause allergies and chronic inflammation.
This article examines the role of dermatophytes, especially Trichophyton rubrum, in sensitizing the body and triggering allergic reactions. Despite the prevalence of chronic dermatophytoses, their allergenic potential is not well understood. Evidence shows T. rubrum can cause IgE-mediated reactions due to prolonged exposure to the allergen Tri r 2, a serine protease. The study discusses how the immune response shifts to a Th2 profile, leading to hypersensitivity and chronic inflammation. The authors highlight the need to include dermatophyte allergens in diagnostic panels and call for more research to create personalized treatments for chronic mycoses and related allergies.
