This study observed that using the LMNN algorithm improved diagnostic accuracy in identifying biomarker correlations associated with hair loss, suggesting potential for advanced automated diagnostics.
April 2026 in “Journal of Experimental Psychopathology” This study suggests that hair cortisol concentration may not reliably indicate psychological distress or differentiate clinical from non-clinical populations, as observed in a female PhD student over nine years.
February 2026 in “TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES” This study found that hair cortisol concentrations are a more reliable biomarker of long-term stress during pregnancy in Akkeçi goats compared to serum cortisol levels, with significant differences observed in hair matrix period means.
February 2026 in “PubMed” This study observed that while hair density generally increased after PRP-based treatments for nonscarring alopecia, the extent of improvement and associated biomarker changes varied widely among individuals.
January 2026 in “Western Journal of Nursing Research” This study found that collecting hair samples for cortisol analysis is feasible in community-dwelling individuals with longstanding multiple sclerosis, although no significant correlation between hair cortisol levels and perceived chronic stress was observed, highlighting the complexity of stress measurement in this population.
January 2026 in “Al-Furat Journal for Health and Medical Sciences” This study observed that individuals with alopecia areata who had the gut bacterium Enterococcus faecalis exhibited serum biomarker levels closer to healthy controls, suggesting potential benefits for hair growth and immune modulation through its immunoregulatory effects.
January 2026 in “Dermatologic Therapy” This review discusses female pattern hair loss as an early marker of hormonal imbalance and evaluates hormonal and lifestyle interventions, but reports no new clinical results.
December 2025 in “Babcock University Medical Journal” This study found that in patients with Alopecia Areata, CD27 and IL-35 levels were significantly higher in those with bacterial infections, suggesting they may be useful as immunological biomarkers.
November 2025 in “Free Radical Biology and Medicine” This study identified ten potential therapeutic targets and biomarkers for androgenic alopecia, with SOD1 and KL as particularly promising candidates for future therapies.
November 2025 in “Analytical Chemistry” This study developed an ultrahigh-power sonicator to improve protein extraction from hair shafts, followed by advanced proteomic analysis, identifying 239 differentially expressed proteins in fetal growth restriction cases compared to healthy controls, which were validated as potential biomarkers for perinatal diagnostics.
November 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study developed a new method using ultrahigh-power sonication and mass spectrometry to improve protein extraction from hair shafts, identifying 239 differentially expressed proteins related to fetal growth restriction, which were validated as potential noninvasive biomarkers for perinatal diagnostics.
November 2025 in “Psychoneuroendocrinology” This study reported that machine learning analysis of protein profiles in hair segments achieved high accuracy in distinguishing women with non-suicidal self-injury disorder from healthy controls, suggesting hair proteomics as a promising non-invasive biomarker for stress-related psychopathology with potential clinical applications.
September 2025 in “Journal of Clinical Medicine” This study found that patients with vitiligo and alopecia areata had significantly higher serum granulysin levels compared to healthy controls, indicating a potential pathogenic role and suggesting that elevated levels may serve as a biomarker for monitoring disease activity, particularly in active vitiligo cases.
September 2025 in “Journal of Intellectual Disability Research” This study investigated the feasibility of measuring scalp hair glucocorticoids as a stress indicator in older adults with intellectual disabilities and found moderate feasibility overall, with higher success in females and those with moderate disabilities, but lower feasibility in males, particularly those balding.
September 2025 in “International Journal of Molecular Sciences” In this review, researchers explored hair as a promising tool for identifying biomarkers in schizophrenia, highlighting its potential for supporting personalized medicine through ease of sampling, though acknowledging challenges like individual variability and methodological inconsistencies.
July 2025 in “Journal of Investigative Dermatology” Three molecular subtypes of advanced skin T-cell lymphoma were identified, with potential biomarkers for predicting treatment response and disease progression.
In this study, female patients with Female Pattern Hair Loss were found to have significantly lower serum levels of vitamin D and ferritin, as well as lower total cholesterol and triglyceride levels, compared to healthy controls, suggesting these factors may contribute to the condition's pathogenesis.
July 2025 in “Arab Board Medical Journal” This study found that patients with androgenetic alopecia had significantly higher serum NF-κB levels compared to controls, and these levels correlated with disease severity, suggesting NF-κB as a potential biomarker and therapeutic target.
June 2025 in “International Journal of Computational Intelligence Systems” This study introduces a novel computational model using fuzzy logic and multi-criteria decision-making techniques to create a triage system for androgenetic alopecia management, stratifying patients into seven severity levels and aiding in resource allocation and treatment planning.
March 2025 in “Medical Science Journal for Advance Research” This study assessed miR-155 levels in the blood of patients with alopecia areata and found significantly different levels compared to healthy controls, indicating that miR-155 may play a significant role in the disease's pathogenesis.
March 2025 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that hair proteomics may serve as a promising, non-invasive biomarker source for stress-associated psychopathology, showing high accuracy in distinguishing patients with non-suicidal self-injury disorder from healthy controls.
November 2024 in “Journal of Investigative Dermatology” Certain NK cell changes in blood may indicate alopecia areata progression.
September 2024 in “Texila international journal of public health” In this study at Sree Balaji Medical College and Hospital, researchers evaluated clinical biomarkers in adolescent and middle-aged women, finding significant differences in SHBG, AMH, and insulin levels between groups, which suggests compensatory hyperinsulinemia may contribute to PCOS development.
April 2024 in “The Journal of urology/The journal of urology” In this study, researchers found that methylation of the SRD5A2 gene in blood and tissue samples can serve as a biomarker to predict men's clinical response to finasteride treatment for benign prostatic hyperplasia, offering a non-invasive method for assessing potential treatment success.
April 2024 in “Journal of wildlife diseases” This study reported that captive muskoxen in Fairbanks, Alaska have significantly faster and variable guard hair growth rates compared to free-ranging Greenland muskoxen, indicating that a universal hair growth rate cannot be applied across different muskox populations or time periods.
March 2024 in “International journal of molecular sciences” This study found that human meibomian glands differ significantly from free and hair-associated sebaceous glands in morphology and lipid composition, making them highly specialized holocrine glands.
March 2024 in “Skin research and technology” This study found that CRP levels were elevated in alopecia areata patients, with an inverse linear association between serum vitamin D and CRP levels specifically noted in ophiasis AA.
May 2023 in “Journal of Student Research” This article discusses the challenges in diagnosing PCOS due to symptom overlap and emphasizes the need for biomarker development to improve early detection; it reports no new clinical results.
April 2023 in “Cancer Research” This study demonstrated that human plucked hairs can be used as a valuable biomarker to evaluate the pharmacodynamic responses of various chemotherapy agents ex vivo, supporting their potential use for assessing oncology drug target engagement prior to clinical studies.
March 2023 in “Journal of Personalized Medicine” During LIFEHOUSE, researchers documented distinct patterns of physical exam findings and biomarker abnormalities in 369 adult employees, which may aid clinicians in recognizing wellness challenges and preventing chronic diseases associated with aging.