Abstract 4350: Pharmacodynamic Biomarkers: Evaluation of Oncology Drug Target Engagement in Human Plucked Scalp and Beard Hair

    April 2023 in “ Cancer Research
    Greg Tudor, Frida Ponthan, Adam Boanas, Aude-Marine Bonavita, Catherine Booth
    TLDR Plucked hair can effectively monitor drug effects in cancer treatment.
    The study presents a method for evaluating drug target engagement in oncology using plucked human scalp and beard hair as a surrogate biomarker tissue. This minimally invasive approach allows for frequent sampling and provides proof of concept data before clinical trials. The research demonstrated that plucked hair can effectively measure pharmacodynamic responses to chemotherapeutic agents, such as Gemcitabine, Tarceva, and Carboplatin, by analyzing changes in specific biomarkers like p-Chk1, p-ERK1/2, and g-H2AX. The findings suggest that plucked hair is a valuable tool for monitoring drug effects and optimizing clinical study designs.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

    Similar Research

    5 / 1000+ results
      Proceedings of the Ninth World Congress for Hair Research 2015

      research Proceedings of the Ninth World Congress for Hair Research 2015

      January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”
      The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.
      Minoxidil: A Comprehensive Review

      research Minoxidil: A Comprehensive Review

      16 citations, June 2021 in “Journal of Dermatological Treatment”
      Minoxidil effectively treats hair loss, especially androgenetic alopecia, but needs more research for better understanding.