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This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

Sex and race affect immune responses and treatment outcomes in Hidradenitis suppurativa.

This study highlights the use of hair and fingernail cortisol levels as retrospective indicators of chronic stress, particularly in minoritized populations facing social stressors that increase the risk of mental health issues.

This study found that sex bias exists in dermatological research, with 60% of articles not reporting the sex of cells or animals and a disproportionate use of male cells and animals when known.

In this study, researchers used single-cell RNA sequencing to identify cell types and molecular differences in subcutaneous adipose tissue from various anatomical sites, suggesting that certain subpopulations of human adipose stem cells might improve the treatment of chronic refractory wounds.

This review suggests that understanding the biological and molecular reasons for more severe COVID-19 in men, particularly those at risk for prostate cancer, could improve management of these patients, but reports no new results.

This review discusses biological sex differences in COVID-19 outcomes and reports no new clinical results; it identifies a need for studies to clarify how sex influences disease progression.

This review examines biological reasons for sex-based differences in COVID-19 outcomes, noting that females exhibit stronger immune responses, potentially explaining lower severity and mortality compared to males.

This study found that aged C57BL/6 mice sub-strains exhibit distinct aging patterns, including differences in survival rates, body weight changes, and disease incidences, providing valuable insights for geriatric research using these mice models.

Men have worse COVID-19 outcomes than women due to genetic and hormonal differences.

This review reports that ritlecitinib, baricitinib, and deuruxolitinib, all JAK inhibitors, are effective treatments for moderate-to-severe alopecia areata, with differences in selectivity and onset of action, and suggests that emerging biologic therapies may enhance treatment by offering more targeted immune modulation.

This study used advanced analytical techniques to reveal that proteins and lipids are distributed unevenly in hair, with distinct structural differences depending on their location within the fiber.

This review examines the phytochemistry, biological activities, and potential applications of Akebia species in medicine and cosmetology, highlighting the differences in chemical composition between A. quinata and A. trifoliata.

This study found that humans have a significantly slower wound-healing rate compared to non-human primates and other animals, suggesting that slow wound healing is a characteristic unique to humans within the primate order and potentially indicating evolutionary adaptations.

This narrative review explores gender differences in the epidemiology, risk factors, and effects of COVID-19, emphasizing the need for further analysis using comprehensive gender indicators to shape effective public health strategies and policies.

This review outlines the biological effects of various placental extracts, noting their reported antioxidant, anti-inflammatory, and immunomodulatory activities, but highlights that the relationship between these effects and the extracts' specific contents remains unclear.

This study identified non-structural proteins in preschool children's scalp hair that suggest potential biomarkers for brain development, immune function, and stress response with heritability and age-related differences.

In this study, researchers observed that chronic stress affected wild-derived house mice differently by sex, with females showing less weight gain and distinct behavioral changes, while males exhibited higher hair corticosterone levels, suggesting divergent coping strategies and implications for sex-specific stress assessment protocols.

This review discusses the use of adipose tissue and platelet-rich plasma in tissue repair and regeneration, noting their promise in surgical outcomes but emphasizing the need for further research to optimize therapies.

This study conducted a meta-analysis and found that among therapies for alopecia areata, baricitinib_4 mg was most likely to be effective, followed by ritlecitinib and ivarmacitinib, while other treatments like dupilumab and secukinumab were less effective.

This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.

This study found that shift nurses exhibited lower circadian variations compared to daytime nurses, indicating an adjustment of their biological clocks to continuous shift schedules.

This study found that patients with ovarian metastases from breast cancer had a better prognosis after tumor debulking if they exhibited high estrogen and progesterone receptor expression in both the primary tumor and metastases.

This review discusses sex and gender differences in COVID-19 presentation, treatment, and outcomes, and reports no new clinical findings.

This study found significant differences in gene expression between newborn and adult skin, with infant skin notably increasing processes related to ECM organization, cell adhesion, and collagen fibril organization.

This study developed a model using cardiovascular radiomics to estimate biological heart age, finding obesity and other health factors strongly correlated with accelerated heart aging.

In this study, researchers identified significant differences in lipid composition between grey and black hair follicles in women with type 2 diabetes and healthy controls, suggesting these lipids may contribute to the production of grey hair and may offer targets for anti-grey-hair treatments.

This review analyzed how the chirality of peptide building blocks affects their self-assembly into hydrogels, comparing structural and mechanical properties of homochiral and heterochiral peptides, and discussed potential biological applications of these peptide systems.

This study describes the characteristics and potential research applications of the first hairless guinea pigs in Iran, noting their suitability for allergy, dermal, transplantation, and immunology studies.