Gender Differences in Patients With COVID-19: A Narrative Review

    Immacolata Ambrosino, Elena Barbagelata, Elena Ortona, Anna Ruggieri, Grace Massiah, Orazio Valerio Giannico, Cecilia Politi, Anna Maria Moretti
    Studysummary This narrative review explores gender differences in the epidemiology, risk factors, and effects of COVID-19, emphasizing the need for further analysis using comprehensive gender indicators to shape effective public health strategies and policies.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The narrative review on gender differences in COVID-19 patients indicated that men were at a higher risk of severe outcomes and mortality compared to women. This was attributed to biological factors like hormonal influences and immune response variations, as well as higher rates of comorbidities in men. The review also discussed the role of sex-specific biomarkers and androgens in influencing disease severity. It emphasized the need for gender-specific approaches in managing and treating COVID-19 to improve patient outcomes.
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