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    Biological Effects of Human Placental Extracts: Variations in Manufacturing Methods and Compositions

    December 2025 in “ Frontiers in Pharmacology ”
    Yikelamu Alimu, Takeshi Yamamoto, Yasukazu Nakahata
    Studysummary This review outlines the biological effects of various placental extracts, noting their reported antioxidant, anti-inflammatory, and immunomodulatory activities, but highlights that the relationship between these effects and the extracts' specific contents remains unclear.
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    Research cited in this study 8

    1. Protective Effect and Mechanism of Placenta Extract on Liver Nutrients · 2022
    2. Antioxidant Capacity and Protective Effect of Cow Placenta Extract on D-Galactose-Induced Skin Aging in Mice Nutrients · 2022
    3. Human Placenta Hydrolysates: From V.P. Filatov to the Present Day: Review Terapevticheskii arkhiv · 2022
    4. Antiviral Effects of Human Placenta Hydrolysate (Laennec®) Against SARS-CoV-2 In Vitro and in the Ferret Model The Journal of Microbiology · 2021
    5. Human Placental Extract: A Potential Therapeutic in Treating Osteoarthritis Annals of Translational Medicine · 2021
    6. Human Placenta Induces Hair Regrowth in Chemotherapy-Induced Alopecia via Inhibition of Apoptotic Factors and Proliferation of Hair Follicles BMC Complementary Medicine and Therapies · 2020
    7. Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells International Journal of Molecular Medicine · 2015
    8. The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study Journal of The European Academy of Dermatology and Venereology · 2012