2 citations
,
May 2023 in “Photobiomodulation, photomedicine, and laser surgery” This editorial reviews how photobiomodulation therapy might effectively treat both hyperpigmentation and depigmentation skin disorders, but reports no new clinical results.
89 citations
,
February 1993 in “Journal of Medicinal Chemistry” This research article focuses on nonsteroidal inhibitors of human type I steroid 5-alpha-reductase but reports no new results.
20 citations
,
June 1995 in “Tetrahedron Letters” This study reported that newly synthesized phenanthridin-3-one derivatives effectively inhibit human steroid 5-α-reductase.
66 citations
,
January 1987 in “Journal of Investigative Dermatology” This study found that enzyme activity critical to cancer induction by polycyclic aromatic hydrocarbons in human hair follicles increased after using a crude coal tar-containing shampoo for four days and was substantially inhibited by imidazole compounds.
May 2010 in “Europe PMC (PubMed Central)” This chapter discusses the synthesis and analysis of near-infrared fluorescent activity-based probes for imaging cysteine protease activity, reporting potential benefits for disease diagnosis but noting challenges in imaging specific locations with high cathepsin activity.
April 2016 in “Journal of Investigative Dermatology” This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.
14 citations
,
June 1952 in “The BMJ” Phenobarbitone can cause severe and sometimes fatal skin reactions.
3 citations
,
May 1979 in “PubMed”
7 citations
,
August 2019 in “Bioorganic & medicinal chemistry” This study identified novel 4-Amino-2H-benzo[h]chromen-2-one analogs as potent androgen receptor antagonists that show strong antiproliferative activity against prostate cancer cells, suggesting them as potential lead compounds for therapy development.
December 2022 in “Ecological Chemistry and Engineering S” This study synthesized indole-acenaphthylene compounds using a magnetic nanocatalyst and explored their photoluminescence properties for detecting copper ions in a mixed solvent system, achieving a detection limit of 9.5 ∙ 10 –6 M.
January 2025 in “Ciência Rural” This case study reports a cutaneous adverse drug reaction in a dog caused by prolonged topical exposure to benzyl benzoate, leading to irritant contact dermatitis, but healing occurred within three weeks after changing treatment.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrates that extracellular ATP induced by UV radiation promotes melanin production in human melanocytes, suggesting ATP-induced purinergic signaling may influence skin pigmentation.
97 citations
,
December 2010 in “Journal of Neuroscience” This study found that midazolam, unlike clonazepam, increased neurosteroid levels and affected synaptic inhibition and plasticity in rat hippocampal neurons, suggesting unique actions via dual receptor activation.
6 citations
,
May 2022 in “Journal of Organometallic Chemistry” This study developed a catalytic system using indenyl-molybdenum(II)-bipyridine complexes and ionic liquid solvents to achieve a 95% yield of campholenic aldehyde from α-pinene oxide under mild conditions.
8 citations
,
March 2002 in “Archiv Der Pharmazie” In this study, 4-(4-(phenylaminocarbonyl)benzoyl) benzoic acid exhibited the strongest inhibitory activity against the human type 2 steroid 5α-reductase isozyme among the compounds tested.
5 citations
,
January 2011 in “International Journal of Cosmetic Science” This study found that 1,2,3,4-tetrahydroquinoline derivatives, particularly N-methyl-7-amino-1,2,3,4-tetrahydroquinoline, may be excellent blue dye candidates for human hair, offering superior color purity, stability, and fastness compared to 2,3-dihydroindoles.
8 citations
,
January 2018 in “European journal of dermatology/EJD. European journal of dermatology” The girl's regrown brown hair had less of certain pigments than her original black hair.
7 citations
,
March 2022 in “Molecules” This study found that 5-bromo-3,4-dihydroxybenzaldehyde (BDB) promoted hair growth in rat vibrissa follicles by activating Wnt/β-catenin and autophagy pathways and inhibiting the TGF-β pathway in dermal papilla cells.
13 citations
,
August 2007 in “Bioorganic & medicinal chemistry letters” This study developed a new competitive 5alpha-reductase inhibitor with an IC(50) of 0.84 microM using a novel chemical structure.
3 citations
,
January 2025 in “Journal of Natural Products” In this study, researchers isolated new compounds from the plant *Calanthe cardioglossa* and found that five of these compounds, particularly calancardin B, significantly reduced TNF-α levels in immune cells relevant to multiple sclerosis, suggesting potential for immunomodulatory effects.
4 citations
,
January 2014 in “RSC Advances” A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
10 citations
,
September 2022 in “Journal of Biophotonics” This study analyzed clinical and histological reports and concluded that blue light therapy is safe for human skin, with potential photoprotective effects against UV irradiation due to its impact on skin pigmentation mediated by Opsin-3.
8 citations
,
November 2019 in “International Journal of Pharmaceutics” This work explores using a liquid crystalline phase to stabilize benzoyl peroxide nanosuspensions, suggesting a promising method to potentially reduce the side effects of acne treatments.
November 2005 in “Physiology” This article highlights advances in various physiological studies, including vitamin E's potential to improve aging-related outcomes in mice, but does not present new experimental results.
8 citations
,
January 2011 in “Organic and Biomolecular Chemistry” Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.
60 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.
5 citations
,
September 2014 in “Journal of Pharmaceutical Sciences”
April 2018 in “Journal of Investigative Dermatology” In this first-in-human study, BLZ-100, an intraoperative fluorescent imaging agent, was administered to 21 patients before skin cancer surgery and was found to be well tolerated without serious adverse effects, suggesting its potential to help distinguish cancerous from non-cancerous tissue based on fluorescence.
1 citations
,
March 2022 in “Journal of burn care & research” This case study highlights that even professional eyebrow tinting can lead to chemical burns, and increasing consumer awareness is crucial as its popularity grows and unregulated products become more common.
January 2026 in “International Journal of Medical Science” This randomized controlled trial reported that combining 0.1% Adapalene with 2.5% Benzoyl Peroxide significantly improved mild acne outcomes in patients compared to Adapalene alone, with greater efficacy noted particularly among females, younger individuals, and those who are non-obese.