Topical Adapalene Versus Adapalene Plus Benzoyl Peroxide in Acne Vulgaris

January 2026 in “ International Journal of Medical Science ”

Aiman Wazir, Md. Abdur Rahim, Laila A. Mahmood

adapalene benzoyl peroxide acne vulgaris topical gel combination therapy monotherapy anti-inflammatory bactericidal Differin Epiduo

TLDR Combining Adapalene with Benzoyl Peroxide is more effective for treating mild acne than using Adapalene alone.

This study compared the efficacy of topical Adapalene (0.1% gel) as Monotherapy versus its combination with 2.5% Benzoyl Peroxide in treating mild Acne Vulgaris. Conducted at Hayatabad Medical Complex, Peshawar, it involved 162 patients divided into two groups. Group B, receiving the combination therapy, showed a significantly higher improvement rate (72.8%) compared to Group A with Monotherapy (51.9%), with a p-value of 0.006. The combination therapy was particularly effective for females, younger patients, and non-obese individuals, due to its synergistic anti-inflammatory and bactericidal effects. The study suggests that the dual regimen is a more successful treatment option for mild Acne, with significant implications for dermatological practice in Pakistan.

View this study on internationaljournalssrg.org →

Discuss this study in the Community →

Similar Research

6 / 299 results

research Side Effects of Common Acne Treatments

38 citations , November 2012 in “Expert Opinion on Drug Safety”

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

research A Comprehensive Review of Acne Vulgaris

18 citations , June 2019 in “Clinical research in dermatology”

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

research Acne Protection: Measures and Miseries

January 2019 in “ARC journal of pharmaceutical sciences”

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

research A Review of Diagnosis and Treatment of Acne in Adult Female Patients

116 citations , December 2017 in “International Journal of Women's Dermatology”

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Adapalene–Benzoyl Peroxide, A Unique Fixed-Dose Combination Topical Gel For The Treatment Of Acne Vulgaris: A Transatlantic, Randomized, Double-Blind, Controlled Study In 1670 Patients

research Adapalene–Benzoyl Peroxide, A Unique Fixed-Dose Combination Topical Gel For The Treatment Of Acne Vulgaris: A Transatlantic, Randomized, Double-Blind, Controlled Study In 1670 Patients

January 2011 in “Yearbook of Dermatology and Dermatologic Surgery”

The adapalene-benzoyl peroxide gel works better and faster for acne treatment than using either ingredient alone, with manageable side effects.

research Epidemiology and Management of Acne in Adult Women

5 citations , January 2014 in “Current Dermatology Reports”

Many adult women suffer from persistent or late-onset acne, and while various treatments exist, finding the right one can be challenging.

Topical Adapalene Versus Adapalene Plus Benzoyl Peroxide in Acne Vulgaris

Related Community Posts Join

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

community This could be it!!! New treatment increase hair 500%

community Minoxidil works only with Retinoic acid

community Can I use adapalene instead of tretinoin for minoxidil absorption?

community Any information on if adapalene also increases sulfotransferase the same way tretinoin does?

community the ordinary retinol & minoxidil