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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Wnt ligands are crucial for hair growth and repair.

CDP is crucial for lung and hair follicle cell development.

Telocytes might help with skin repair and regeneration.

Blocking JAK-STAT signaling can lead to hair growth.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Peptide hydrogels heal burn wounds faster and better than standard dressings.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Cathepsin L is essential for normal hair growth and development.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.