February 1999 in “Strength and Conditioning Journal” Androstenedione, a hormone supplement, doesn't improve muscle or performance and can cause harmful side effects.
56 citations
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October 2018 in “Journal of The American Academy of Dermatology” This review discusses the role of androgens in women's skin-related conditions like acne, hirsutism, and female pattern hair loss, noting the lack of dermatology guidelines for when to pursue endocrinologic evaluation.
16 citations
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August 1989 in “Human Reproduction” This article discusses the complex pathogenesis of hirsutism and reports no new clinical results; further research is needed for better diagnostic and therapeutic strategies.
14 citations
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September 2017 in “Clinics in Dermatology” This study highlights that lower testosterone in men and higher testosterone in women are linked to increased risks of metabolic syndrome and type 2 diabetes, with associated skin diseases indicating potential cardiovascular complications.
7 citations
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June 1994 in “Journal of The American Academy of Dermatology” This report describes a possible case of burn-induced bullous pemphigoid, as the disease was transient and did not recur, suggesting a potential link between burns and the condition.
July 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers found that the efflux of calcium in root hairs of Arabidopsis thaliana, particularly through the ER-localized ACA2 and ACA7, is crucial for modulating cytoplasmic calcium signals and enabling proper root hair growth, with disruptions leading to impaired elongation.
November 2025 in “Frontiers in Pharmacology” In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.
February 2025 in “East African Scholars Journal of Medical Sciences” In this study conducted at Bangabandhu Sheikh Mujib Medical University, researchers reported that males with androgenetic alopecia had significantly higher levels of serum LH, prolactin, testosterone, DHEA-S, and free androgen index, and lower levels of serum FSH and SHBG compared to those without hair loss.
December 2023 in “International Journal of Research in Dermatology” This study evaluated hormonal differences in males with early androgenetic alopecia, finding increased serum testosterone, prolactin, LH, LH/FSH, and FAI levels, with decreased FSH and SHBG levels, compared to controls without hair loss.
September 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study found a significant negative correlation between serum SHBG levels and androgenetic alopecia severity in women, but not in men, while no significant correlation was observed for testosterone, estradiol, dehydroepiandrosterone sulfate, and vitamin D levels with hair loss severity across genders.
January 2019 in “Indian Dermatology Online Journal” This study found that female pattern hair loss is the most common type of diffuse hair loss in women, with significant associations observed between chronic telogen effluvium, low iron levels, and high total iron-binding capacity.
January 2008 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study found that the gene for the enzyme aromatase is expressed in scalp hair follicles of women and is negatively correlated with LH levels, potentially reflecting the hormonal environment of hair follicles in PCOS.
May 2017 in “Endocrine Abstracts” This study found that men with early-onset androgenetic alopecia who also met criteria for the male PCOS-equivalent may have impaired gonadal steroidogenesis, suggesting increased risk of future gonadal dysfunction.
This study found that in female androgenetic alopecia, androgen receptors are highly positive in affected areas, supporting their role as regulators of genetically predisposed hair follicles despite normal serum hormone levels.
17 citations
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May 2003 in “Journal of The American Academy of Dermatology” This study found that miniaturized hair follicles from pattern alopecia can regenerate rapidly when transplanted onto mice and may grow as well as or better than terminal hairs.
January 2026 in “American Journal of Medical Genetics Part A” The researchers reported two brothers with a new variant of X-linked trichothiodystrophy associated with an RNF113A gene mutation, highlighting features such as intellectual disability and growth failure, but without previously reported endocrinological or genital abnormalities, underlining the importance of genetic counseling for such variants.
18 citations
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December 1992 in “Journal of Cutaneous Pathology” This study observed that lectin-binding patterns in skin appendage tumors reveal differences in sweat gland tumors compared to normal tissues, but pilosebaceous tumors maintained a similar lectin-binding pattern to their corresponding normal structures.
10 citations
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November 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported higher dihydrotestosterone and testosterone levels in balding Korean and Caucasian subjects compared to non-balding controls, with variations suggesting racial differences in androgen metabolism.
November 2005 in “Hair transplant forum international” This paper discusses how studying hair follicles in the balding scalp could reveal fundamental biological processes, without reporting new experimental findings.
17 citations
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January 2016 in “American Journal of Epidemiology” This study suggests that any baldness, particularly moderate balding, is associated with a higher risk of fatal prostate cancer in men, supporting a possible link between hair loss and prostate cancer mechanisms.
47 citations
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December 2000 in “Archives of Dermatological Research” This study found that women with androgenetic alopecia showed higher levels of certain hormones and lower levels of sex hormone-binding globulin than healthy controls, potentially linking these factors to alopecia severity.
April 2021 in “Journal of Investigative Dermatology” A deep learning model was developed to help diagnose trichothiodystrophy by analyzing hair patterns.
April 2012 in “Informa Healthcare eBooks” Fibrosing alopecia in a pattern distribution is a unique hair loss condition with inflammation and scarring, resembling but distinct from common balding.
November 1986 in “PubMed” In this study, women with male pattern alopecia had significantly lower serum sex hormone binding globulin levels compared to healthy controls, while testosterone levels remained similar.
6 citations
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January 1985 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” This study found that epithelial components of calcifying epithelioma of Malherbe showed lectin binding and keratin staining patterns similar to normal hair follicles, with prominent Con A staining in tumor giant cells.
50 citations
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September 2009 in “Molecular Genetics and Metabolism” This study identified a novel V26M mutation in the vitamin D receptor as the cause of hereditary vitamin D resistant rickets in a patient, characterized by severe rickets and an unusual pattern of alopecia.
January 2013 in “China Animal Husbandry & Veterinary Medicine” This study found that IGFBP-5 may play a significant regulatory role in the hair follicle development of Inner Mongolia Cashmere goats, with more consistent expression patterns across different stages.
32 citations
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March 2018 in “Neoplasia” This study suggests that nephronectin (NPNT) could serve as a novel prognostic marker for poor prognosis in a subgroup of breast cancer patients, associated with specific NPNT staining patterns.
2 citations
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January 2020 in “Journal of The European Academy of Dermatology and Venereology” Balding men have harder scalps.
32 citations
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March 1987 in “Journal of The American Academy of Dermatology” Using minoxidil on balding men's scalps can increase hair growth, according to a 12-month study.